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Rabbit Monoclonal STK39 Antibody

  • 中文名： STK39抗体
  • 别    名： DCHT; PASK; SPAK; Stk39;;STK39
货号: IPDX18791
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesDCHT; PASK; SPAK; Stk39;;STK39
WB Predicted band sizeCalculated MW: 59 kDa ; Observed MW: 68 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human STK39
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇与STK39抗体相关的文献摘要示例(虚构内容，供参考格式)：

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1. **文献名称**: *STK39 regulates sodium transport in renal cells via phosphorylation signaling*

**作者**: Zhang Y, et al.

**摘要**: 本研究利用STK39特异性抗体，通过Western blot和免疫荧光技术，揭示了STK39激酶在肾脏上皮细胞中通过磷酸化NKCC2蛋白调控钠离子重吸收的机制，为高血压相关研究提供新靶点。

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2. **文献名称**: *Expression profiling of STK39 in hepatocellular carcinoma using immunohistochemistry*

**作者**: Liu X, Wang H.

**摘要**: 通过商业化STK39抗体对肝癌组织进行免疫组化分析，发现STK39在肿瘤组织中显著高表达，且与患者预后不良相关，提示其可能作为肝癌诊断的生物标志物。

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3. **文献名称**: *STK39 interacts with WNK kinases in cellular osmotic stress response*

**作者**: Morales F, et al.

**摘要**: 本研究采用STK39抗体进行共免疫沉淀实验，证实STK39与WNK激酶家族在细胞渗透压应激下的相互作用，阐明其在细胞体积调控通路中的关键作用。

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如需真实文献，建议通过PubMed或Google Scholar检索关键词“STK39 antibody”或“SPAK antibody”获取近期研究。

背景信息

The STK39 antibody targets the serine/threonine kinase 39 (STK39), also known as SPAK (STE20/SPS1-related proline-alanine-rich kinase), a protein encoded by the *STK39* gene in humans. STK39 is a member of the STE20 kinase family and plays a critical role in cellular responses to osmotic stress, ion transport regulation, and blood pressure homeostasis. It interacts with cation-chloride cotransporters (e.g., NKCC1. NKCC2) and the WNK kinase pathway, modulating their activity via phosphorylation. Dysregulation of STK39 has been linked to hypertension, neurological disorders, and cancer progression. Antibodies against STK39 are essential tools for studying its expression, localization, and function in tissues or cell lines. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research applications include exploring STK39's role in salt-sensitive hypertension, neuronal excitability, and cellular stress signaling. Commercial STK39 antibodies are typically validated for specificity using knockout controls or siRNA-mediated knockdown. Both monoclonal and polyclonal variants are available, often targeting conserved regions such as the kinase domain or N-terminal regulatory sequences. Reliable STK39 antibodies are critical for elucidating its physiological and pathological mechanisms.

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