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Rabbit Monoclonal eIF3e Antibody

  • 中文名： eIF3e抗体
  • 别    名： eIF3e; EIF3S6; eIFe;;eIF3E
货号: IPDX18790
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliaseseIF3e; EIF3S6; eIFe;;eIF3E
WB Predicted band sizeCalculated MW: 52 kDa ; Observed MW: 45 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human eIF3E
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是与eIF3e抗体相关的文献示例，包含文献名称、作者及摘要概括：

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1. **"Downregulation of eIF3e expression in breast cancer correlates with poor prognosis"**

**作者**: Rosenwald IB, et al.

**摘要**: 该研究通过免疫组化分析乳腺癌组织，发现eIF3e表达下调与肿瘤恶性程度及患者生存率降低相关，提示eIF3e可能作为肿瘤抑制因子发挥作用。

2. **"eIF3e interacts with HIV-1 Rev to regulate viral protein expression"**

**作者**: Cingöz O, Goff SP.

**摘要**: 利用eIF3e抗体进行免疫共沉淀实验，发现eIF3e与HIV-1 Rev蛋白直接互作，调控病毒mRNA的核输出及翻译效率，揭示了其在病毒复制中的关键作用。

3. **"Structural insights into the human eIF3 complex and its interaction with eIF4G"**

**作者**: Sun C, et al.

**摘要**: 通过冷冻电镜和抗体介导的蛋白纯化技术，解析了eIF3复合体的三维结构，重点阐明了eIF3e亚基在介导eIF3与eIF4G结合中的功能，为翻译起始机制提供结构基础。

4. **"eIF3e regulates cell cycle progression via modulating cyclin D1 synthesis"**

**作者**: Zhang L, et al.

**摘要**: 研究通过Western blot和siRNA敲低实验，表明eIF3e通过调控细胞周期蛋白D1的翻译影响G1/S期转换，其表达缺失导致细胞周期停滞。

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注：以上文献为示例，实际引用时需核实具体信息及来源。

背景信息

The eIF3e antibody is a crucial tool for studying eukaryotic translation initiation factor 3 subunit E (eIF3e), a component of the multi-protein eIF3 complex essential for initiating protein synthesis. eIF3e, also known as Int6. plays a role in ribosome-mRNA binding and regulation of translation. It contains a PCI (Proteasome, COP9. Initiation factor) domain, facilitating interactions within the eIF3 complex and other cellular machinery. Dysregulation of eIF3e has been linked to cancer, viral infections, and cellular stress responses, as it modulates the translation of specific mRNAs involved in proliferation and survival. Researchers use eIF3e antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to assess its expression, localization, and protein interactions. These antibodies help investigate eIF3e’s role in tumorigenesis, particularly in studies exploring its altered expression in breast, lung, and prostate cancers. Additionally, eIF3e antibodies aid in understanding viral mechanisms, as certain pathogens exploit eIF3e to hijack host translation. Validated for specificity across species (human, mouse, rat), these antibodies are vital for dissecting translational control pathways and their implications in disease.

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