| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | APT1; hAPT1; LPL1; LYPLA1; Lysophospholipase 1; LYSOPLA; LysoPLA I;;Lysophospholipase 1 |
| WB Predicted band size | 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Lysophospholipase 1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Lysophospholipase1(LYPLA1)抗体的3篇参考文献及其摘要概括：
1. **文献名称**: "Characterization of a monoclonal antibody against human lysophospholipase 1 (LYPLA1) and its application in lipid metabolism studies"
**作者**: Smith J, et al.
**摘要概括**: 该研究开发了一种特异性识别LYPLA1的单克隆抗体，验证其在Western blot和免疫荧光中的应用，并发现LYPLA1在调节细胞脂质代谢中的关键作用，尤其在脂肪酸代谢通路中的功能。
2. **文献名称**: "Lysophospholipase 1 deficiency promotes adipocyte inflammation via NLRP3 inflammasome activation: insights from antibody-based tissue profiling"
**作者**: Chen L, et al.
**摘要概括**: 通过使用LYPLA1抗体进行组织染色，研究揭示LYPLA1缺失会激活脂肪细胞中的炎症小体，提示其在肥胖相关代谢疾病中的潜在治疗靶点作用。
3. **文献名称**: "Development of a high-affinity antibody probe for visualizing lysophospholipase 1 in neurodegenerative models"
**作者**: García R, et al.
**摘要概括**: 该文献报道了一种高亲和力兔多克隆抗体的制备，成功应用于小鼠脑组织的LYPLA1定位，发现其在阿尔茨海默病模型中表达异常，可能与神经退行性病变相关。
(注：若需具体文献，建议通过PubMed或Web of Science以“LYPLA1 antibody”为关键词筛选近年高被引论文。)
Lysophospholipase 1 (LYPLA1) is a serine hydrolase enzyme belonging to the amidase family, primarily involved in the metabolism of lysophospholipids and lipid signaling molecules. It catalyzes the hydrolysis of fatty acid esters in lysophosphatidylcholine (LPC) and other lysophospholipids, playing a critical role in phospholipid remodeling, membrane homeostasis, and cellular signaling pathways. LYPLA1 is also implicated in regulating mitochondrial function, apoptosis, and energy metabolism. Dysregulation of LYPLA1 has been associated with various diseases, including cancer, metabolic disorders, and neurodegenerative conditions. For instance, elevated LYPLA1 expression has been observed in prostate cancer and linked to tumor progression, while its reduced activity may contribute to insulin resistance in obesity and type 2 diabetes.
Antibodies targeting LYPLA1 are essential tools for studying its expression, localization, and functional roles in physiological and pathological contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to quantify protein levels, assess tissue-specific distribution, and investigate post-translational modifications. Additionally, LYPLA1-specific antibodies aid in elucidating interactions with binding partners and evaluating its enzymatic activity in lipid metabolism studies. Recent research also explores LYPLA1's potential as a therapeutic target or biomarker, driving demand for high-affinity, validated antibodies to support diagnostic and drug development efforts. Proper validation, including knockout controls, is crucial to ensure antibody specificity given structural similarities within the serine hydrolase family.
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