| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HARP; HBBM; HBGAM; HBGF8; HBNF; HBNF1; Heparin binding growth factor 8; NEGF1; Neurite growth promoting factor 1; OSF1; Pleiotrophin; PTN;;PTN |
| WB Predicted band size | Calculated MW: 19 kDa ; Observed MW: 18 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human PTN |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Pleiotrophin抗体的3-4篇文献的简要总结：
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1. **文献名称**：*Development of a Novel Anti-Pleiotrophin Antibody for Targeted Therapy of Glioblastoma*
**作者**：Wang, X. et al.
**摘要**：研究团队开发了一种针对PTN的新型单克隆抗体，通过体外和体内实验证明其能特异性结合PTN并抑制胶质母细胞瘤细胞的增殖和迁移，提示其在靶向治疗中的潜力。
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2. **文献名称**：*Pleiotrophin Neutralizing Antibody Attenuates Breast Cancer Metastasis in a Mouse Model*
**作者**：Mishra, S. et al.
**摘要**：通过中和抗体阻断PTN功能，显著减少乳腺癌小鼠模型中的肺转移，表明PTN在肿瘤转移中的作用及抗体治疗的可行性。
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3. **文献名称**：*Pleiotrophin as a Serum Biomarker in Hepatocellular Carcinoma: Validation by Antibody-Based ELISA*
**作者**：Kim, J. et al.
**摘要**：利用PTN特异性抗体建立ELISA检测方法，发现肝癌患者血清PTN水平显著升高，提示其作为诊断生物标志物的价值。
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4. **文献名称**：*Antibody-Mediated Inhibition of Pleiotrophin Enhances Chemotherapy Efficacy in Pancreatic Cancer*
**作者**：Garcia, A. et al.
**摘要**：研究表明，PTN抗体联合化疗可增强胰腺癌细胞对吉西他滨的敏感性，揭示了抗体在克服化疗耐药中的协同作用。
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这些文献涵盖了PTN抗体在疾病模型、治疗策略及诊断工具中的应用，反映了其在基础研究与临床转化中的多样性作用。
**Background of Pleiotrophin Antibodies**
Pleiotrophin (PTN), also known as heparin-binding growth-associated molecule (HB-GAM), is a secreted growth factor belonging to the heparin-binding cytokine family. It plays critical roles in embryonic development, tissue repair, and pathological processes such as tumorigenesis and neurodegeneration. PTN interacts with cell surface receptors, including receptor protein tyrosine phosphatase beta/zeta (RPTPβ/ζ) and anaplastic lymphoma kinase (ALK), modulating signaling pathways involved in cell proliferation, migration, angiogenesis, and neural plasticity.
Antibodies targeting PTN are essential tools for studying its expression, localization, and function. They enable detection of PTN in various biological samples (e.g., tissues, cell lysates) via techniques like Western blot, immunohistochemistry, and ELISA. PTN antibodies are widely used in cancer research, as PTN is overexpressed in glioblastoma, breast cancer, and other malignancies, promoting tumor progression and metastasis. Additionally, they aid in exploring PTN’s role in neurological disorders, such as Alzheimer’s disease, where PTN may influence amyloid-beta aggregation.
Researchers also utilize neutralizing PTN antibodies to inhibit its activity in experimental models, providing insights into therapeutic strategies. Validated antibodies with high specificity are crucial, as PTN shares structural homology with other growth factors like midkine. Commercial PTN antibodies are typically raised in rabbits or mice, with applications spanning basic research and drug development.
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