| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GST; GST class kappa; GST13; Gstk1; hGSTK1;;GSTK1 |
| WB Predicted band size | 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human GSTK1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于GSTK1抗体的3篇参考文献(模拟示例，具体文献需根据实际数据库检索)：
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1. **文献名称**: *"Characterization of GSTK1 Antibody Specificity in Mitochondrial Antioxidant Pathways"*
**作者**: Smith A, et al.
**摘要**: 本研究验证了一种多克隆GSTK1抗体在HeLa细胞线粒体裂解液中的特异性，发现GSTK1在氧化应激条件下表达上调，并通过Western blot和免疫荧光证实其亚细胞定位。
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2. **文献名称**: *"GSTK1 Downregulation in Hepatocellular Carcinoma: Implications for Drug Resistance"*
**作者**: Chen L, et al.
**摘要**: 利用GSTK1单克隆抗体进行免疫组化分析，发现肝癌组织中GSTK1蛋白表达显著降低，其缺失与化疗耐药性增强相关，提示GSTK1可能作为潜在治疗靶点。
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3. **文献名称**: *"Development of a Novel GSTK1 Antibody for Proteomic Analysis of Neurodegenerative Disorders"*
**作者**: Park J, et al.
**摘要**: 开发了一种高灵敏度兔源GSTK1抗体，结合质谱技术分析阿尔茨海默病模型小鼠脑组织，发现GSTK1与tau蛋白异常磷酸化存在调控关联。
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4. **文献名称**: *"Cross-Reactivity Evaluation of Commercial GSTK1 Antibodies in Murine Models"*
**作者**: Gupta R, et al.
**摘要**: 系统性评估了5种市售GSTK1抗体的交叉反应性，发现仅两种抗体在小鼠肝脏和肾脏样本中表现出特异性，强调抗体验证在跨物种研究中的必要性。
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**注意**：以上文献为示例，实际引用需通过PubMed/Google Scholar以“GSTK1 antibody”或“Glutathione S-Transferase Kappa 1”为关键词检索真实研究。
The Glutathione S-transferase kappa 1 (GSTK1) antibody is a tool used to detect and study the GSTK1 protein, a member of the glutathione S-transferase (GST) family. GSTs are enzymes involved in cellular detoxification, metabolism, and oxidative stress response by catalyzing the conjugation of glutathione to toxic compounds. Unlike other GST isoforms localized in the cytoplasm or microsomes, GSTK1 is uniquely targeted to mitochondria, suggesting a specialized role in mitochondrial redox homeostasis and metabolic regulation. GSTK1 has been implicated in processes such as fatty acid metabolism, apoptosis, and inflammation.
The GSTK1 antibody is widely employed in research to investigate its expression patterns, subcellular localization, and interactions in various tissues and disease models. It is commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Studies utilizing this antibody have explored associations between GSTK1 dysregulation and diseases, including diabetes, neurodegenerative disorders, and cancer. For instance, altered GSTK1 expression has been observed in certain cancers, potentially linking it to tumor progression or chemoresistance.
Commercially available GSTK1 antibodies are typically raised against specific epitopes, with validation in knockout controls to ensure specificity. Researchers rely on these antibodies to elucidate GSTK1's functional roles in mitochondrial pathways and its potential as a therapeutic target or biomarker in oxidative stress-related pathologies.
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