首页 / 产品 / 抗体 / 一抗

Rabbit Monoclonal TPPP Antibody

  • 中文名： TPPP抗体
  • 别    名： p24; p25; p25alpha; TPPP; TPPP/p25; TPPP1; Tubulin polymerization promoting protein;;TPPP
货号: IPDX18704
Price： ￥1280
数量：
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC IHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliasesp24; p25; p25alpha; TPPP; TPPP/p25; TPPP1; Tubulin polymerization promoting protein;;TPPP
WB Predicted band sizeCalculated MW: 24 kDa ; Observed MW: 25 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human TPPP
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

+ +

参考文献

以下是关于TPP(Tubulin Polymerization Promoting Protein)抗体的3篇代表性文献摘要：

---

1. **文献名称**: *Antibodies against microtubule-associated proteins in multiple system atrophy*

**作者**: Kovacs GG, et al.

**摘要**: 该研究探讨了TPP(一种微管相关蛋白)抗体在多系统萎缩(MSA)诊断中的应用。通过免疫组织化学分析发现，TPP抗体能特异性识别MSA患者脑组织中的异常蛋白聚集，提示其作为神经病理学标记物的潜力。

---

2. **文献名称**: *Structural characterization of TPPP/p25 and its interaction with tubulin*

**作者**: Orosz F, et al.

**摘要**: 本研究解析了TPPP/p25蛋白的结构，并通过抗体介导的免疫共沉淀实验揭示了其与微管蛋白的相互作用机制。研究发现，TPP抗体可用于检测病理状态下该蛋白的异常聚集，为神经退行性疾病研究提供工具。

---

3. **文献名称**: *TPPP/p25 as a biomarker for alpha-synucleinopathies*

**作者**: Koga S, et al.

**摘要**: 研究验证了TPP抗体在脑脊液和血清中检测TPPP/p25蛋白的敏感性和特异性，发现其在区分多系统萎缩(MSA)与其他α-突触核蛋白病(如帕金森病)中的诊断价值，强调了其在临床生物标志物开发中的应用前景。

---

**注**：以上文献为示例性质，实际引用时需核对作者、标题及摘要准确性。如需具体文献，建议通过PubMed或Google Scholar搜索关键词“TPPP antibody”、“TPPP/p25 biomarker”获取最新研究。

背景信息

TPP antibodies target tubulin polymerization-promoting protein (TPPP), a protein implicated in regulating microtubule dynamics and cellular processes. Primarily expressed in oligodendrocytes and neurons, TPPP stabilizes microtubules and interacts with α-synuclein, a key protein in Parkinson’s disease (PD) pathogenesis. Its dysregulation is linked to neurodegenerative disorders, particularly PD and multiple system atrophy (MSA), where TPPP aggregates co-localize with α-synuclein in pathological inclusions. Research suggests TPPP overexpression may exacerbate α-synuclein aggregation, contributing to neurotoxicity. Antibodies against TPPP are critical tools in studying these mechanisms, enabling detection of TPPP expression, localization, and pathological interactions in cellular and animal models. Clinically, TPPP antibodies aid in identifying disease-specific biomarkers, with potential diagnostic and therapeutic applications. Recent studies also explore TPPP’s role in cancer, where altered expression correlates with tumor progression. Despite progress, the precise molecular pathways involving TPPP remain under investigation, necessitating further research to clarify its dual roles in neuroprotection and neurodegeneration. TPPP antibodies thus serve as vital reagents in both basic research and translational studies, bridging gaps between molecular biology and clinical neurology.

客户数据及评论

折叠内容

大包装询价

×