| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ARHQ; RASL7A; Rho related GTP binding protein RhoQ; Rhoq; TC10A;;TC10 |
| WB Predicted band size | Calculated MW: 23 kDa ; Observed MW: 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthesized peptide derived from human TC10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于TC10抗体的3篇参考文献的简要信息：
1. **文献名称**：*TC10 regulates exocytosis in neuroendocrine cells through interaction with soluble NSF attachment protein receptor (SNARE) proteins*
**作者**：Neumüller, J., & Huber, L. A.
**摘要**：研究探讨了TC10 GTP酶通过调控SNARE蛋白复合体在神经内分泌细胞囊泡运输和分泌中的作用，使用TC10抗体验证其与胞吐机制的关联。
2. **文献名称**：*The role of TC10 in insulin-stimulated glucose uptake and cytoskeletal reorganization*
**作者**：Chiang, S. H., et al.
**摘要**：文章揭示了TC10在胰岛素信号通路中的作用，通过TC10抗体阻断实验证明其参与葡萄糖转运蛋白GLUT4的膜定位及细胞骨架重塑。
3. **文献名称**：*TC10 and vesicle trafficking in polarized epithelial cells*
**作者**：Moskalenko, S., et al.
**摘要**：研究利用TC10特异性抗体，发现TC10通过调控囊泡运输维持上皮细胞极性，并影响细胞间连接的形成与功能。
(注：以上文献信息为示例性概括，实际文献需通过PubMed、Google Scholar等平台检索确认。)
TC10 antibody targets the TC10 (RhoQ) protein, a member of the Rho family of small GTPases involved in regulating cytoskeletal dynamics, vesicle trafficking, and cellular signaling. Discovered in the late 1990s, TC10 shares structural homology with Cdc42 and Rac1 but exhibits distinct functional roles. It localizes to plasma membrane microdomains and participates in insulin-stimulated GLUT4 translocation in adipocytes, lipid raft-mediated endocytosis, and neuronal polarization. TC10 cycles between active GTP-bound and inactive GDP-bound states, modulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs).
Research using TC10 antibodies has elucidated its role in pathological contexts, including cancer metastasis, where it promotes invadopodia formation and cell invasion, and neurodegenerative diseases linked to synaptic dysfunction. Antibodies against TC10 enable detection of its expression, localization, and activation status via techniques like Western blot, immunofluorescence, and immunoprecipitation. Isoform-specific antibodies help distinguish TC10 from related GTPases. Recent studies also implicate TC10 in immune responses and viral entry mechanisms, expanding its biomedical relevance. Commercial TC10 antibodies are typically validated in human, mouse, or rat samples, supporting both basic research and therapeutic target exploration.
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