| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CLG; CLGN; MMP1;;MMP1 |
| WB Predicted band size | 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human MMP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于MMP1抗体的3-4条参考文献示例(内容为虚构，仅供格式参考)：
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1. **文献名称**：*"A High-Specificity Monoclonal Antibody for MMP1 Detection in Human Tissues"*
**作者**：Zhang, Y. et al.
**摘要**：本研究开发了一种针对人MMP1的高特异性单克隆抗体，通过免疫组化验证其在乳腺癌组织中的表达，显示其与肿瘤侵袭性显著相关，为临床诊断提供新工具。
2. **文献名称**：*"Neutralizing MMP1 Antibody Attenuates Collagen Degradation in Rheumatoid Arthritis"*
**作者**：Tanaka, K. et al.
**摘要**：报道了一种中和性MMP1抗体，可有效抑制类风湿关节炎滑膜细胞中胶原酶活性，减轻关节损伤，提示其治疗潜力。
3. **文献名称**：*"Comparative Evaluation of Commercial MMP1 Antibodies in Serum Biomarker Analysis"*
**作者**：Müller, R. & Schmidt, J.
**摘要**：系统比较了5种市售MMP1抗体在ELISA和Western blot中的性能，推荐抗体X适用于血清样本的高灵敏度检测。
4. **文献名称**：*"MMP1-Targeted Antibody-Conjugated Nanoparticles for Imaging Tumoral Stroma"*
**作者**：Chen, L. et al.
**摘要**：构建了MMP1抗体偶联的纳米探针，成功应用于小鼠模型中肿瘤基质的活体成像，增强早期癌症检测的精准度。
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注：以上文献为示例，实际引用需查询权威数据库(如PubMed)。如需真实文献，建议通过关键词“MMP1 antibody”、“monoclonal antibody MMP1”等进行检索。
Matrix metalloproteinase 1 (MMP1), also known as interstitial collagenase, is a zinc-dependent endopeptidase belonging to the MMP family. It plays a critical role in degrading extracellular matrix (ECM) components, particularly fibrillar collagens (types I, II, and III), facilitating tissue remodeling, wound healing, and embryonic development. Dysregulated MMP1 expression is implicated in pathological processes such as cancer metastasis, rheumatoid arthritis, and cardiovascular diseases.
MMP1 antibodies are immunological tools designed to detect, quantify, or inhibit MMP1 in research and diagnostic applications. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to study MMP1 expression patterns in normal vs. diseased tissues. Some antibodies target specific MMP1 domains (e.g., catalytic or hemopexin-like regions) to investigate its activation, interactions, or enzymatic activity. Monoclonal antibodies offer high specificity, while polyclonal antibodies may detect broader epitopes.
In therapeutic contexts, MMP1-blocking antibodies are explored for modulating excessive collagen degradation in chronic inflammatory or fibrotic disorders. However, challenges remain due to MMP family homology and off-target effects. Research on MMP1 antibodies continues to advance understanding of ECM dynamics and their role in disease progression, offering potential for biomarker discovery or targeted therapies.
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