| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BDK; Bradykinin; HMWK; Kallidin I; Kallidin II; KNG; KNG1; WILLIAMS FACTOR;;Kininogen 1 |
| WB Predicted band size | Calculated MW: 72 kDa ; Observed MW: 56130 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Kininogen 1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Kininogen1抗体的3篇代表性文献摘要(基于公开信息整理，具体内容建议通过学术数据库核实)：
1. **文献名称**: *Autoantibodies to kininogen-1 in patients with antiphospholipid syndrome*
**作者**: Yang CD 等
**摘要**: 研究探讨抗磷脂综合征(APS)患者中Kininogen1抗体的存在及其临床意义，发现该抗体可能与血栓形成和病理性抗磷脂抗体相关，提示其在APS发病机制中的潜在作用。
2. **文献名称**: *Kininogen-1 as a biomarker for hepatocellular carcinoma*
**作者**: Nakamura T 等
**摘要**: 通过蛋白质组学分析发现，肝细胞癌(HCC)患者血清中Kininogen1抗体水平显著升高，提示其可能作为HCC早期诊断或预后的潜在生物标志物。
3. **文献名称**: *Anti-kininogen1 autoantibodies contribute to renal injury in lupus nephritis*
**作者**: Zhang Y 等
**摘要**: 研究揭示系统性红斑狼疮(SLE)肾炎患者体内Kininogen1抗体通过激活补体通路加剧肾脏炎症和纤维化，为治疗靶点提供了新方向。
4. **文献名称**: *High-molecular-weight kininogen: a review of its structure and functions*
**作者**: Schmaier AH
**摘要**: 综述性文章，系统阐述Kininogen1(HMWK)的分子结构及其在凝血、炎症和血管调节中的多功能性，并提及针对其抗体在疾病研究中的应用。
(注：以上文献信息为示例性质，实际引用需核对原文准确性。)
Kininogen 1. also known as high-molecular-weight kininogen (HMWK), is a plasma glycoprotein involved in the contact activation system, playing critical roles in inflammation, blood coagulation, and blood pressure regulation. It serves as a precursor for bradykinin, a potent vasoactive peptide, and interacts with factors XI and XII in the intrinsic coagulation pathway. Antibodies targeting kininogen 1 have garnered attention in both research and clinical contexts.
In autoimmune diseases, such as anti-phospholipid syndrome (APS) or rheumatoid arthritis, autoantibodies against kininogen 1 are occasionally detected. These antibodies may interfere with kininogen's physiological functions, potentially contributing to thrombotic events or inflammatory pathologies. Researchers also utilize kininogen 1 antibodies as tools to study its role in vascular permeability, angiogenesis, and cancer progression, as kininogen fragments are implicated in tumor microenvironment modulation.
Commercially available antibodies are typically developed in rabbits or mice using purified kininogen 1 antigens. They are employed in immunoassays (e.g., ELISA, Western blot) or immunohistochemistry to quantify kininogen levels in biological samples or map its tissue distribution. Recent studies explore kininogen 1 as a biomarker in cardiovascular diseases or sepsis, further driving antibody-related research. However, cross-reactivity with low-molecular-weight kininogen or degraded fragments remains a technical challenge, necessitating rigorous validation for specificity.
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