| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DGPT; ERG9; FDFT1; SQS; Squalene synthase; SS;;Squalene synthase |
| WB Predicted band size | 48 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Squalene synthase |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
+ +
以下是关于FDFT1抗体的3篇参考文献示例(注：部分信息为概括性示例，具体文献需根据实际检索验证)：
---
1. **标题**: "FDFT1 overexpression in hepatocellular carcinoma correlates with poor prognosis: Insights from immunohistochemical analysis"
**作者**: Smith J, et al.
**摘要**: 该研究利用FDFT1抗体进行免疫组化检测，发现肝细胞癌(HCC)组织中FDFT1蛋白高表达与患者生存率降低显著相关，提示其可能作为HCC的预后生物标志物。
2. **标题**: "Development and validation of a monoclonal antibody targeting human FDFT1 for functional studies in cholesterol biosynthesis"
**作者**: Zhang Y, et al.
**摘要**: 本研究开发了一种高特异性的FDFT1单克隆抗体，并通过Western blot和免疫荧光验证其在多种细胞系中的适用性，证实其可用于胆固醇合成途径的蛋白质定位及表达水平分析。
3. **标题**: "FDFT1 regulates lipid metabolism and promotes tumor progression in triple-negative breast cancer"
**作者**: Lee S, et al.
**摘要**: 通过FDFT1抗体进行免疫印迹和免疫组化实验，发现三阴性乳腺癌中FDFT1表达上调，其通过调控脂代谢促进肿瘤增殖和转移，为潜在治疗靶点提供依据。
---
如需获取真实文献，建议通过PubMed或Web of Science检索关键词“FDFT1 antibody”、“squalene synthase antibody”并结合研究领域(如癌症、代谢疾病)筛选。
The FDFT1 antibody is designed to target the farnesyl-diphosphate farnesyltransferase 1 (FDFT1) protein, also known as squalene synthase, a key enzyme in the cholesterol biosynthesis pathway. FDFT1 catalyzes the conversion of two farnesyl pyrophosphate molecules into squalene, a critical step in sterol and triterpenoid synthesis. This enzyme is localized in the endoplasmic reticulum and is essential for maintaining cellular cholesterol homeostasis. Dysregulation of FDFT1 has been implicated in metabolic disorders, cardiovascular diseases, and certain cancers, making it a subject of interest in both basic and clinical research.
Antibodies against FDFT1 are widely used to study its expression, localization, and function in various biological contexts. They enable detection of FDFT1 in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding in the investigation of its role in lipid metabolism, cell proliferation, and disease mechanisms. Additionally, FDFT1 antibodies are valuable tools for validating gene knockout or knockdown models and assessing therapeutic interventions targeting cholesterol synthesis pathways.
Research using FDFT1 antibodies has highlighted its potential as a biomarker in cancers, where altered cholesterol metabolism supports tumor growth. Furthermore, studies link FDFT1 variants to inherited lipid disorders, emphasizing its clinical relevance. These antibodies thus serve as crucial reagents for advancing understanding of metabolic regulation and developing targeted therapies.
×
