| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AITD3; hTG; TDH3; Tg; TGN; Thyroglobulin;;Thyroglobulin |
| WB Predicted band size | 305 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Thyroglobulin |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于甲状腺球蛋白抗体(Thyroglobulin Antibodies, TgAb)的3篇代表性文献摘要：
1. **文献名称**：*"Thyroglobulin autoantibodies: epitopes and immunoglobulin subclasses"*
**作者**：Ruf J, Carayon P
**摘要**：该研究分析了TgAb在自身免疫性甲状腺疾病(如桥本甲状腺炎)中的表位特异性及抗体亚型分布，发现不同疾病状态下TgAb识别的甲状腺球蛋白表位存在差异，可能与疾病进展相关。
2. **文献名称**：*"Thyroid autoimmunity: mechanisms and clinical impact"*
**作者**：McLachlan SM, Rapoport B
**摘要**：综述探讨了TgAb的产生机制及其在甲状腺功能异常中的临床意义，强调其作为诊断标志物在鉴别Graves病与桥本甲状腺炎中的作用，并讨论抗体水平与疾病活动度的关联。
3. **文献名称**：*"Clinical implications of thyroglobulin antibody measurement in differentiated thyroid cancer"*
**作者**：Spencer CA
**摘要**：研究指出TgAb的存在会干扰甲状腺球蛋白(Tg)的检测准确性，提出在甲状腺癌术后监测中需同步检测TgAb以提高病情评估的可靠性，并探讨了抗体持续阳性的预后意义。
4. **文献名称**：*"Genetic and environmental factors affecting thyroglobulin antibody production"*
**作者**：Hansen PS, Brix TH, Hegedüs L
**摘要**：通过双胞胎研究分析遗传与环境因素对TgAb产生的影响，发现HLA-DR基因多态性与抗体阳性率显著相关，同时碘摄入量和吸烟等环境因素可能调控抗体表达水平。
注：以上文献为领域内代表性研究方向示例，实际引用时需核对具体文献来源及细节。
Thyroglobulin antibodies (TgAbs) are autoantibodies targeting thyroglobulin (Tg), a large glycoprotein produced by thyroid follicular cells. Tg serves as a precursor for thyroid hormone synthesis, storing iodine and providing the backbone for triiodothyronine (T3) and thyroxine (T4) production. TgAbs arise due to immune system dysregulation, often in autoimmune thyroid disorders.
These antibodies are most notably associated with Hashimoto's thyroiditis and Graves' disease, where they contribute to thyroid tissue destruction or functional disruption. Their presence is a hallmark of autoimmune thyroiditis, aiding in diagnosis alongside other thyroid autoantibodies (e.g., anti-TPO). TgAbs are detected via immunoassays and are present in ~10-20% of healthy individuals, with higher prevalence in women and increasing with age.
Clinically, TgAbs interfere with Tg measurements, complicating monitoring in thyroid cancer patients post-thyroidectomy. Since Tg is a tumor marker for residual or recurrent disease, TgAbs can falsely lower Tg levels in immunometric assays, necessitating alternative monitoring methods. Current guidelines recommend concurrent TgAb testing during Tg evaluation to ensure accuracy. While their pathogenic role remains unclear, TgAbs may participate in immune-mediated thyroid damage through antibody-dependent cytotoxicity or immune complex deposition. Research continues to explore their prognostic value and interplay with other autoimmune markers.
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