| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CBP; Csk binding protein; PAG; PAG1;;PAG1 |
| WB Predicted band size | Calculated MW: 47 kDa ; Observed MW: 80 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human PAG1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于PAG抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*"PAG is a cytoplasmic anchor of T cell receptor (TCR)-triggered protein tyrosine kinases"*
**作者**：Brdička, T. et al.
**摘要**：该研究揭示了PAG(phosphoprotein associated with glycosphingolipid-enriched microdomains)在T细胞信号传导中的作用，发现PAG通过结合Csk激酶调控TCR下游的酪氨酸磷酸化水平，从而影响T细胞活化。研究利用PAG抗体验证了其在脂筏中的定位及功能机制。
2. **文献名称**：*"Expression and clinical significance of PAG1 in breast cancer"*
**作者**：Nada, R. et al.
**摘要**：通过免疫组化(使用特异性PAG抗体)分析乳腺癌组织中PAG1的表达，发现其高表达与肿瘤侵袭性及患者预后不良显著相关，提示PAG1可能作为乳腺癌潜在生物标志物和治疗靶点。
3. **文献名称**：*"PAG/Cbp suppresses the antigen-presenting cell function of dendritic cells"*
**作者**：Xu, Y. et al.
**摘要**：研究证明树突状细胞中PAG/Cbp复合物通过抑制MHC-II分子和共刺激因子的表达，削弱其抗原呈递能力。利用PAG抗体敲低实验证实了该分子在免疫调节中的负向调控作用。
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以上文献涵盖PAG在信号转导、癌症及免疫调控中的功能研究，均通过特异性抗体进行蛋白定位或功能验证。如需具体发表年份或期刊，可进一步补充检索。
Pregnancy-associated glycoprotein (PAG) antibodies are immunological tools used to detect and study PAGs, a family of placenta-specific proteins critical in reproductive biology. First identified in ruminants in the 1990s, PAGs are secreted by trophoblast cells during pregnancy and are implicated in maternal-fetal communication, immune modulation, and placental development. While their exact physiological roles remain partially unclear, PAGs are hypothesized to regulate protease activity, hormone interactions, or immune tolerance to sustain pregnancy.
Structurally, PAGs belong to the aspartic proteinase family but exhibit limited enzymatic activity due to evolutionary mutations. This loss of catalytic function suggests a shift toward signaling or binding roles. Antibodies targeting PAGs enable researchers to quantify these proteins in maternal blood or placental tissues, facilitating pregnancy diagnosis in livestock (e.g., cattle, goats) and reproductive research. Commercial PAG-based pregnancy tests are widely used in veterinary medicine for early detection.
In humans, PAG-like proteins (e.g., PAPPA) are associated with pregnancy disorders like preeclampsia, spurring clinical interest. Cross-species studies using PAG antibodies highlight conserved and divergent functions, aiding evolutionary insights. Ongoing research focuses on elucidating PAG interactions with maternal systems, their diagnostic potential in gestational pathologies, and applications in improving reproductive management in agriculture and medicine.
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