| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SSTR5; SS5R; Sstr5;;SS5R |
| WB Predicted band size | Calculated MW: 39 kDa ; Observed MW: 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human SS5R |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于SSTR5抗体的参考文献摘要示例(注：文献信息为虚构示例，仅供格式参考)：
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1. **"Development of a High-Affinity Monoclonal Antibody Targeting SSTR5 for Neuroendocrine Tumor Imaging"**
*Authors: Müller, C. et al.*
**摘要**: 研究报道了一种新型SSTR5单克隆抗体的开发，该抗体通过噬菌体展示技术筛选，表现出对SSTR5的高特异性和亲和力。体外实验证实其在神经内分泌肿瘤细胞系中有效结合，并成功应用于小鼠模型的PET成像，为肿瘤诊断提供新工具。
2. **"SSTR5 Antibody-Based ELISA for Quantification of Receptor Expression in Gastrointestinal Cancers"**
*Authors: Zhang, L. et al.*
**摘要**: 本研究建立了一种基于SSTR5抗体的ELISA检测方法，用于定量分析胃肠道肿瘤组织中SSTR5的表达水平。临床样本验证显示，SSTR5高表达与肿瘤分化程度相关，提示其作为预后生物标志物的潜力。
3. **"Targeted Therapy Using SSTR5-Specific Antibody-Drug Conjugates in Pancreatic Cancer Models"**
*Authors: Rossi, G. et al.*
**摘要**: 研究评估了SSTR5抗体-药物偶联物(ADC)在胰腺癌治疗中的效果。体内实验表明，ADC能选择性杀伤SSTR5阳性肿瘤细胞，显著抑制小鼠异种移植瘤生长，且毒性可控，为靶向治疗提供实验依据。
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*注：实际文献需通过PubMed、Google Scholar等平台检索关键词"SSTR5 antibody"或"SSTR5 somatostatin receptor"，结合具体研究领域筛选。*
The somatostatin receptor subtype 5 (SSTR5) is a G protein-coupled receptor that binds somatostatin and cortistatin, playing critical roles in regulating hormone secretion, cell proliferation, and neurotransmission. It is predominantly expressed in neuroendocrine tissues, including the brain, pancreas, and gastrointestinal tract, as well as in various neuroendocrine tumors (NETs). SSTR5 antibodies are immunological tools designed to detect, quantify, or modulate SSTR5 activity in research and clinical settings. These antibodies are pivotal in studying SSTR5's physiological functions, such as its involvement in insulin/glucagon regulation, or pathological roles in diseases like pituitary adenomas, pancreatic NETs, and certain cancers.
In diagnostics, SSTR5-specific antibodies aid in immunohistochemical profiling of tumors to guide targeted therapies, particularly for patients resistant to SSTR2-focused treatments (e.g., octreotide). Therapeutically, SSTR5-targeting monoclonal antibodies or antibody-drug conjugates are under exploration for delivering cytotoxic agents to SSTR5-positive cancer cells. Additionally, SSTR5 antibodies are used in molecular imaging, enabling precise tumor localization via radiolabeled probes. Recent studies also highlight their utility in understanding SSTR5 signaling crosstalk with other receptors, such as dopamine receptors, opening avenues for combination therapies. Despite progress, challenges remain in optimizing antibody specificity and minimizing off-target effects, which are critical for advancing clinical applications.
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