| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Bmp6; DVR6; VGR; VGR1;;BMP6 |
| WB Predicted band size | Calculated MW: 57 kDa ; Observed MW: 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human BMP6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于BMP6抗体的示例参考文献(注：以下为模拟示例，实际文献请通过学术数据库查询)：
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1. **"Development of a High-Specificity Monoclonal Antibody for BMP6 Detection"**
*作者：Smith A, et al.*
**摘要**：本研究报道了一种新型抗BMP6单克隆抗体的开发，通过ELISA和免疫组化验证其特异性，成功应用于小鼠组织样本中BMP6蛋白的定位分析，为BMP6相关疾病研究提供工具。
2. **"BMP6 Antibody Neutralization in Iron Homeostasis Studies"**
*作者：Chen L, et al.*
**摘要**：利用抗BMP6抗体阻断其信号通路，揭示BMP6在肝脏铁调素(hepcidin)调控中的关键作用，为遗传性血色素沉着症的治疗策略提供实验依据。
3. **"BMP6 Expression in Renal Fibrosis: Insights from Antibody-Based Inhibition"**
*作者：Wang Y, et al.*
**摘要**：通过抗BMP6抗体中和实验，证明BMP6在肾纤维化模型中促进上皮-间质转化(EMT)，提示靶向BMP6可能延缓慢性肾病进展。
4. **"Role of BMP6 in Osteosarcoma Metastasis: Antibody-Mediated Functional Analysis"**
*作者：Garcia R, et al.*
**摘要**：使用抗BMP6抗体抑制肿瘤微环境中的BMP6活性，发现其可减少骨肉瘤细胞的迁移和侵袭能力，表明BMP6信号通路在癌症转移中的潜在治疗价值。
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建议通过PubMed、Google Scholar等平台，以关键词“BMP6 antibody”、“BMP6 neutralization”或“BMP6 immunohistochemistry”检索真实文献。
The BMP6 (Bone Morphogenetic Protein 6) antibody is a tool used to detect and study BMP6. a member of the transforming growth factor-beta (TGF-β) superfamily. BMP6 plays critical roles in regulating cellular processes such as osteogenesis, iron metabolism, and tissue homeostasis. It binds to type I and II serine/threonine kinase receptors, activating SMAD-dependent signaling pathways. Dysregulation of BMP6 is linked to disorders like anemia, fibrosis, and cancer, making it a target for therapeutic research.
BMP6 antibodies are typically developed in host species like rabbits or mice and can be polyclonal or monoclonal. They are used in applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and ELISA to visualize BMP6 expression and localization in tissues or cells. Specificity is validated using knockout controls or blocking peptides. Neutralizing BMP6 antibodies are also employed to inhibit its biological activity, aiding in functional studies. Researchers rely on these antibodies to explore BMP6's role in disease mechanisms, signaling crosstalk, and potential therapeutic interventions. Commercial BMP6 antibodies often undergo rigorous validation to ensure reproducibility in experimental models.
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