WB | 1/1000-1/2000 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
ICC | 1/50-1/200 | Human,Mouse,Rat |
FCM | 1/20-1/100 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Aliases | desmoglein-2; DSG2; HDGC; ARVD10; CDHF5; CMD1BB;;Desmoglein 2 |
WB Predicted band size | Calculated MW: 122 kDa ; Observed MW: 160 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Mouse,Rat |
Immunogen | A synthesized peptide derived from human Desmoglein 2 |
Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Desmoglein 2(Dsg2)抗体的3篇参考文献示例(内容为模拟,建议查证实际文献):
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1. **文献名称**: *Autoantibodies against Desmoglein 2 contribute to pathogenesis in arrhythmogenic right ventricular cardiomyopathy*
**作者**: López-Ayala JM, et al.
**摘要**: 研究发现在致心律失常性右室心肌病(ARVC)患者血清中检测到抗Dsg2自身抗体,这些抗体可能通过破坏心肌细胞间桥粒连接,促进心肌细胞凋亡和纤维脂肪浸润,加速疾病进展。
2. **文献名称**: *Desmoglein 2 as a novel biomarker in breast cancer progression*
**作者**: Sánchez R, et al.
**摘要**: 该研究表明,乳腺癌患者中Dsg2的表达异常与肿瘤侵袭性相关,同时发现部分患者血清中存在抗Dsg2抗体,提示其可能作为癌症诊断或预后评估的潜在标志物。
3. **文献名称**: *Desmoglein 2 regulates apoptosis via EGFR/ERK signaling in epithelial cells*
**作者**: Tselepis C, et al.
**摘要**: 通过体外实验证实,Dsg2抗体可通过干扰表皮生长因子受体(EGFR)信号通路,激活ERK依赖的细胞凋亡机制,揭示了Dsg2在维持上皮细胞存活中的关键作用。
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**备注**:以上内容为示例,实际文献需通过PubMed、Google Scholar等数据库检索确认。
Desmoglein 2 (DSG2) is a transmembrane glycoprotein belonging to the desmoglein subfamily of cadherins, primarily involved in forming desmosomes—specialized intercellular junctions critical for tissue integrity and mechanical stability in epithelial and myocardial cells. These adhesion complexes mediate cell-cell interactions through calcium-dependent binding, playing essential roles in tissue morphogenesis, homeostasis, and barrier function. DSG2 is ubiquitously expressed, distinguishing it from other desmogleins (e.g., DSG1/3) with tissue-specific roles.
Antibodies targeting DSG2 have dual contexts: pathological autoantibodies and research/clinical tools. In autoimmune disorders, DSG2 autoantibodies are less commonly implicated than DSG1/3 antibodies (linked to pemphigus). However, emerging studies associate anti-DSG2 antibodies with arrhythmogenic cardiomyopathy (ACM), where they may disrupt desmosomal function, contributing to myocardial inflammation and fibrosis. Such autoimmunity might arise from molecular mimicry post-viral infections or genetic predisposition.
In research, DSG2-specific antibodies are vital for studying desmosome assembly, cell adhesion dynamics, and DSG2’s non-canonical roles in signaling pathways, including EGFR and Wnt. They are also investigated in cancer, as DSG2 overexpression in certain tumors correlates with invasion and metastasis. Therapeutic antibodies or inhibitors targeting DSG2 are being explored to modulate cell adhesion in diseases like cancer or autoimmune conditions. However, their clinical application requires further validation of specificity and safety to avoid off-target effects on normal tissues reliant on DSG2 function.
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