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Rabbit Monoclonal Osteocalcin Antibody

  • 中文名: Osteocalcin抗体
  • 别    名: BGLAP; BGP; OCN; Osteocalcin; PMF1;;Osteocalcin
货号: IPDX18456
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/1000-1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesBGLAP; BGP; OCN; Osteocalcin; PMF1;;Osteocalcin
WB Predicted band sizeCalculated MW: 11 kDa ; Observed MW: 16 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human Osteocalcin
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇关于Osteocalcin抗体的代表性文献摘要(虚拟示例,仅供参考):

1. **文献名称**: *"Production and characterization of monoclonal antibodies specific for osteocalcin"*

**作者**: Lee NK, et al.

**摘要**: 报道了针对人源Osteocalcin的单克隆抗体制备及特异性验证,通过免疫印迹和ELISA证实其可识别骨组织及血清中的完整Osteocalcin分子,适用于骨代谢研究。

2. **文献名称**: *"Osteocalcin as a biomarker of bone turnover: Antibody-based assays and clinical applications"*

**作者**: Karsenty G, et al.

**摘要**: 系统评估了不同Osteocalcin抗体在骨代谢疾病(如骨质疏松症)中的检测效能,探讨抗体特异性对临床诊断结果的影响,并比较羧化与非羧化形式Osteocalcin的检测差异。

3. **文献名称**: *"Standardization of osteocalcin measurements: Role of antibody epitope recognition in immunoassays"*

**作者**: Vasikaran S, et al.

**摘要**: 分析了不同抗体对Osteocalcin不同表位(如N端、C端或中间片段)的识别差异,提出标准化检测流程以减少实验误差,强调抗体选择对结果可比性的重要性。

4. **文献名称**: *"Cross-reactivity of osteocalcin antibodies in non-skeletal tissues: Implications for endocrine function studies"*

**作者**: Ferron M, et al.

**摘要**: 研究Osteocalcin抗体在非骨骼组织(如胰腺、睾丸)中的交叉反应性,揭示其在激素样功能研究中的潜在干扰因素,建议优化抗体验证方法以提高实验特异性。

(注:以上为模拟内容,实际文献需通过PubMed或学术数据库检索确认。)

背景信息

Osteocalcin, a small non-collagenous protein predominantly synthesized by osteoblasts, plays a critical role in bone mineralization and metabolic regulation. As a vitamin K-dependent protein, it undergoes gamma-carboxylation post-translationally, enabling calcium binding to hydroxyapatite crystals during bone formation. Recent studies also highlight its endocrine functions, particularly in glucose metabolism and cognitive processes. Osteocalcin antibodies are essential tools for detecting and quantifying this protein in research and clinical settings. These antibodies are widely used in techniques like ELISA, Western blotting, and immunohistochemistry to study bone remodeling dynamics, osteoporosis, fracture healing, and metabolic disorders. Polyclonal antibodies offer broad epitope recognition, while monoclonal variants provide high specificity, making them suitable for differentiating between carboxylated (inactive) and uncarboxylated (hormonally active) osteocalcin isoforms. Species-specific antibodies (e.g., human, mouse, rat) enable cross-species comparative studies. Validation in relevant biological samples is crucial due to osteocalcin's low serum concentrations and structural variations. Emerging applications include investigating osteocalcin's role in diabetes, neurodegenerative diseases, and its crosstalk with organs like pancreas and brain. Reliable osteocalcin antibodies remain pivotal for advancing bone biology research and developing diagnostic/therapeutic strategies for skeletal and metabolic disorders.

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