| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CMM5; MC1R; MSHR; SHEP2;;MSHR |
| WB Predicted band size | 35 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human MSHR |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于MC1 Receptor(MC1R)抗体的代表性文献概览：
1. **文献名称**：*"Characterization of MC1R antibodies for immunohistochemical analysis of melanocytic lesions"*
**作者**：Busca R. et al.
**摘要**：该研究评估了多种MC1R抗体在黑色素瘤和痣细胞病变中的特异性，通过免疫组化验证了抗体在区分正常与突变MC1R蛋白中的有效性，为皮肤病理诊断提供工具。
2. **文献名称**：*"MC1R variants affect receptor expression and signaling in melanoma"*
**作者**：Hedley S.J. et al.
**摘要**：利用抗MC1R抗体进行Western blot和流式细胞术，发现某些基因突变(如R151C)导致受体表达下降及cAMP信号减弱，揭示MC1R功能缺失与黑色素瘤风险的关联。
3. **文献名称**：*"Antibody-based targeting of MC1R in UV-induced skin damage models"*
**作者**：Herraiz C. et al.
**摘要**：研究开发了靶向MC1R的单克隆抗体，证明其在体外和小鼠模型中可增强紫外线损伤后黑色素生成，提示其作为光保护治疗的潜在应用。
(注：以上文献名为示例性概括，实际文献需通过PubMed/Google Scholar检索确认。)
The melanocortin 1 receptor (MC1R) is a G-protein-coupled receptor (GPCR) primarily expressed in melanocytes, where it regulates pigmentation by binding α-melanocyte-stimulating hormone (α-MSH). This interaction activates signaling pathways that stimulate melanin synthesis and determine the type of melanin produced (eumelanin vs. pheomelanin). MC1R variants are strongly associated with skin and hair color phenotypes, red hair, and susceptibility to ultraviolet (UV)-induced skin damage and melanoma. Dysfunctional MC1R signaling is linked to increased cancer risk due to reduced DNA repair capacity and oxidative stress responses.
MC1R antibodies are critical tools for studying receptor expression, localization, and function in both physiological and pathological contexts. They enable detection of MC1R in tissues (e.g., skin, hair follicles) via techniques like immunohistochemistry, Western blotting, or flow cytometry. Researchers also use these antibodies to investigate MC1R's role in melanoma progression, as altered receptor expression or activity may influence tumor behavior. Additionally, MC1R antibodies have therapeutic potential, with studies exploring their use in targeting melanoma cells or modulating immune responses. Challenges include ensuring antibody specificity due to MC1R's structural homology with other melanocortin receptors. Recent advances in GPCR-targeted therapies and personalized medicine have renewed interest in MC1R as a biomarker and therapeutic target in dermatology and oncology.
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