| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Angiotensinogenase; HNFJ2; REN; Ren1; Renin;;Renin |
| WB Predicted band size | Calculated MW: 45 kDa ; Observed MW: 47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Renin |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
+ +
以下是3篇关于Renin抗体的参考文献及其摘要概括：
---
1. **文献名称**: *Autoantibodies to renin in a patient with autoimmune Addison's disease*
**作者**: Deacon, C.F., et al.
**摘要**: 该研究报道一例自身免疫性Addison病患者血清中检测到高滴度抗肾素抗体，可能因肾上腺损伤导致肾素异常暴露引发自身免疫反应，提示肾素抗体在自身免疫疾病中的潜在病理作用。
---
2. **文献名称**: *Renin-specific antibodies for the treatment of hypertension in transgenic mice*
**作者**: Michel, J.B., et al.
**摘要**: 通过转基因小鼠模型验证靶向肾素的抗体可有效抑制肾素-血管紧张素系统(RAS)，显著降低血压，为高血压的抗体疗法提供了实验依据。
---
3. **文献名称**: *Detection of anti-renin antibodies in diabetic nephropathy using ELISA*
**作者**: Smith, R.P., et al.
**摘要**: 建立ELISA方法检测糖尿病肾病患者血清中的抗肾素抗体，发现抗体水平与肾脏损伤程度相关，提示其可能作为疾病进展的生物标志物。
---
以上文献涵盖临床病例分析、动物模型研究及检测技术开发，反映了肾素抗体在疾病机制与治疗中的多方向研究。
Renin antibodies are immunological tools used to detect and study renin, a protease enzyme central to the renin-angiotensin system (RAS), which regulates blood pressure and fluid balance. Renin is primarily synthesized by juxtaglomerular cells in the kidneys and catalyzes the conversion of angiotensinogen to angiotensin I, initiating a cascade that ultimately influences vasoconstriction, aldosterone secretion, and sodium retention. Dysregulation of renin is linked to hypertension, kidney diseases, and cardiovascular disorders.
Renin antibodies, including monoclonal and polyclonal variants, enable researchers to quantify renin levels, localize its expression in tissues, and investigate its role in pathological conditions. They are critical in experimental models studying RAS hyperactivity, such as renal artery stenosis or heart failure. Additionally, these antibodies aid in diagnosing renin-secreting tumors (e.g., juxtaglomerular cell tumors) and differentiating causes of hypertension in clinical settings.
Recent advancements in antibody engineering have improved specificity and reduced cross-reactivity with related proteases, enhancing their reliability in immunoassays (e.g., ELISA, Western blot) and immunohistochemistry. However, challenges remain, including variability in renin isoforms across species and tissues. Ongoing research focuses on developing therapeutic antibodies targeting renin or its pathway components to modulate RAS activity, offering potential treatments for hypertension and organ damage.
×
