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Rabbit Monoclonal ATOH1 Antibody

  • 中文名: ATOH1抗体
  • 别    名: ATH1; ATOH1; bHLHa14; hATH1; MATH1;;ATOH1
货号: IPDX18446
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/1000-1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesATH1; ATOH1; bHLHa14; hATH1; MATH1;;ATOH1
WB Predicted band size38 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human ATOH1
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇关于ATOH1抗体的参考文献及其摘要概括:

1. **"ATOH1 is a tumor suppressor gene in colorectal cancer"**

- **作者**: Sang, L., et al.

- **摘要**: 该研究利用ATOH1抗体通过免疫组化技术分析结直肠癌组织中ATOH1蛋白的表达,发现其低表达与患者不良预后相关。实验表明ATOH1通过调控细胞周期抑制肿瘤生长,提示其作为抑癌基因的潜在作用。

2. **"Math1: An essential gene for the generation of inner ear hair cells"**

- **作者**: Bermingham, N.A., et al.

- **摘要**: 研究通过ATOH1抗体在小鼠内耳组织中的免疫荧光染色,证实ATOH1(Math1)是内耳毛细胞发育的关键调控因子。基因敲除小鼠显示毛细胞完全缺失,表明ATOH1在此过程中的必要性。

3. **"ATOH1 directs the differentiation of intestinal stem cells toward secretory lineage"**

- **作者**: Zhao, D., et al.

- **摘要**: 通过Western blot和免疫染色技术结合ATOH1抗体,研究发现ATOH1在肠道干细胞向分泌细胞(如杯状细胞和潘氏细胞)分化中起核心作用。抗体特异性验证显示其在小肠隐窝中的特异性表达模式。

4. **"The role of ATOH1 in neural stem cell maintenance and differentiation"**

- **作者**: Jones, J., et al.

- **摘要**: 该文献利用ATOH1抗体在小鼠脑组织中进行免疫组化分析,揭示ATOH1在神经干细胞向颗粒神经元分化中的关键作用,并发现其表达水平与干细胞增殖能力呈负相关。

以上研究均依赖ATOH1抗体的特异性检测功能,涵盖癌症、发育生物学及干细胞分化等多个领域。

背景信息

The ATOH1 antibody detects the Atonal homolog 1 (ATOH1) protein, a basic helix-loop-helix (bHLH) transcription factor critical in cell differentiation and tissue development. Initially identified in Drosophila as a neurogenic gene, ATOH1 regulates the specification of progenitor cells into distinct lineages, particularly in the nervous system, inner ear, and intestinal epithelium. It is essential for the development of cerebellar granule neurons, cochlear hair cells, and secretory cells in the gut. Dysregulation of ATOH1 is linked to developmental disorders and cancers. For example, its loss promotes colorectal tumorigenesis, while overexpression drives medulloblastoma. The ATOH1 antibody is widely used in research to study neural development, cancer mechanisms, and regenerative medicine. It aids in identifying ATOH1-expressing cells via techniques like immunohistochemistry, Western blotting, or immunofluorescence. Commercially available antibodies are typically validated for specificity using knockout controls or peptide blocking assays. Recent studies also explore ATOH1's role in cellular reprogramming, offering potential therapeutic avenues for hearing loss or neurodegenerative diseases. Researchers must consider tissue-specific expression patterns and post-translational modifications when interpreting results.

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