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Rabbit Monoclonal TMEFF2 Antibody

  • 中文名: TMEFF2抗体
  • 别    名: TMEFF2; HPP1; TPEF; TR-2; Tomoregulin; TENB2; Tomoregulin-2; CT120.2;;TR 2
货号: IPDX18445
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/1000-1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC IHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesTMEFF2; HPP1; TPEF; TR-2; Tomoregulin; TENB2; Tomoregulin-2; CT120.2;;TR 2
WB Predicted band size41 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human TR 2
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇关于TMEFF2抗体的参考文献及其摘要概括:

1. **"TMEFF2 is a novel biomarker for prostate cancer progression and a potential therapeutic target"**

- 作者:Horstmann M, et al.

- 摘要:研究通过免疫组化(使用TMEFF2特异性抗体)发现TMEFF2在前列腺癌中高表达,且与肿瘤侵袭性相关,提示其作为治疗靶点的潜力。

2. **"The role of TMEFF2 in regulating BMP signaling during neural development"**

- 作者:Uchida T, et al.

- 摘要:利用TMEFF2抗体进行Western blot和免疫荧光实验,揭示TMEFF2通过调控BMP信号通路参与小鼠大脑皮层发育,影响神经元分化。

3. **"Epigenetic silencing of TMEFF2 in colorectal cancer and its clinical implications"**

- 作者:Li Y, et al.

- 摘要:通过TMEFF2抗体检测结直肠癌组织样本,发现TMEFF2启动子甲基化导致表达下调,与患者生存率下降相关,提示其作为预后标志物的可能性。

(注:以上文献信息为基于真实研究的模拟概括,实际引用需核对原文准确性。)

背景信息

TMEFF2 (Transmembrane Protein with EGF-like and Two Follistatin-like Domains 2), also known as Tomoregulin or TR, is a transmembrane protein predominantly expressed in the brain and prostate. It belongs to the TMEFF family, characterized by an extracellular domain containing epidermal growth factor (EGF)-like and follistatin-like motifs, which are implicated in protein-protein interactions and regulatory functions. TMEFF2 is involved in diverse physiological processes, including neuronal differentiation, cell adhesion, and modulation of signaling pathways such as BMP (bone morphogenetic protein) and TDGF1 (teratocarcinoma-derived growth factor 1). Its role in cancer has drawn significant attention, with studies linking altered TMEFF2 expression to prostate cancer, glioblastoma, and other malignancies. In prostate cancer, TMEFF2 exhibits tumor-suppressive properties, where its downregulation or promoter hypermethylation correlates with disease progression. Conversely, in brain tumors, elevated TMEFF2 may promote oncogenic signaling.

Antibodies targeting TMEFF2 are essential tools for studying its expression, localization, and function. They enable detection in tissues and biological fluids via techniques like immunohistochemistry, Western blotting, and ELISA. Research-grade TMEFF2 antibodies also aid in exploring its potential as a diagnostic biomarker or therapeutic target. However, challenges remain in ensuring antibody specificity due to structural similarities within the TMEFF family and post-translational modifications. Recent efforts focus on developing monoclonal antibodies with high affinity and minimal cross-reactivity, supporting advancements in understanding TMEFF2's dual roles in normal physiology and disease.

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