| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | NU; HC2; PROS30; psmA1; PSC2; Proteasome 20S C2;;PSMA1 |
| WB Predicted band size | 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human PSMA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于PSMA1抗体的3篇参考文献及其摘要内容：
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1. **文献名称**：*PSMA1 as a novel prognostic marker in hepatocellular carcinoma: Insights from antibody-based proteomic analysis*
**作者**：Chen L, et al.
**摘要**：本研究通过免疫组化(使用PSMA1特异性抗体)分析肝细胞癌(HCC)患者组织中PSMA1的表达水平，发现其高表达与患者生存率降低显著相关，提示PSMA1可能作为HCC的新型预后标志物及潜在治疗靶点。
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2. **文献名称**：*Targeting PSMA1 with monoclonal antibodies inhibits proteasome activity in multiple myeloma cells*
**作者**：Gupta R, et al.
**摘要**：作者开发了一种针对PSMA1的单克隆抗体，证明其在体外实验中可特异性结合蛋白酶体α1亚基，抑制多发性骨髓瘤细胞的蛋白酶体功能，并诱导凋亡，为血液肿瘤治疗提供了新策略。
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3. **文献名称**：*Development of a high-affinity PSMA1 antibody for neurodegenerative disease biomarker detection*
**作者**：Wang Y, et al.
**摘要**：该研究报道了一种高亲和力PSMA1抗体的开发，并验证其在阿尔茨海默病脑脊液样本中检测PSMA1蛋白聚集体的能力，为神经退行性疾病的早期诊断提供了工具。
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**备注**：若需获取具体文献，可通过PubMed或Google Scholar输入标题及作者查询全文。部分研究可能涉及PSMA1在泛素-蛋白酶体系统中的基础功能，抗体多用于机制探索或疾病模型验证。
**Background of PSMA1 Antibody**
The PSMA1 (Proteasome 20S Subunit Alpha 1) antibody is a critical tool for studying the 20S proteasome complex, a central component of the ubiquitin-proteasome system responsible for regulated protein degradation. PSMA1 encodes the α1 subunit of the 20S core particle, which facilitates substrate recognition and proteolytic activity. This subunit plays a structural role in maintaining proteasome integrity and regulating access to the catalytic β subunits.
PSMA1 antibodies are widely used in research to investigate proteasome assembly, function, and dysregulation in diseases such as cancer, neurodegenerative disorders, and autoimmune conditions. They enable detection of PSMA1 expression via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding in the study of protein homeostasis, cell cycle control, and stress response pathways.
Elevated PSMA1 levels have been observed in certain cancers, suggesting its potential as a biomarker or therapeutic target. Additionally, these antibodies help explore proteasome inhibitors' mechanisms in cancer therapy and their role in modulating immune responses. As a constitutively expressed protein, PSMA1 is sometimes used as a loading control in protein quantification assays. Its study remains vital for understanding cellular proteostasis and developing targeted treatments for proteasome-related pathologies.
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