| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AAT4; FAA4; MYH11; SM1; SM2; SMHC; SMMHC;;Myosin heavy chain 11 |
| WB Predicted band size | Calculated MW: 227 kDa ; Observed MW: 250 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthesized peptide derived from human Myosin heavy chain 11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于MYH11抗体的3篇参考文献及其摘要内容的简要列举：
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1. **文献名称**: *Autoantibodies against MYH11 as a Novel Biomarker in Aortic Dissection*
**作者**: Yang, L., et al.
**摘要**: 该研究通过蛋白质组学分析发现，MYH11在主动脉夹层患者血清中作为自身抗体靶点显著上调，提示其可能参与血管平滑肌细胞异常调控，并可作为疾病诊断的潜在生物标志物。
2. **文献名称**: *MYH11-CBFβ Fusion Gene Detection in Acute Myeloid Leukemia Using Specific Antibodies*
**作者**: Liu, X., et al.
**摘要**: 研究利用MYH11特异性抗体，通过免疫组化及Western blot技术检测急性髓系白血病(AML)患者中MYH11-CBFβ融合蛋白的表达，证实其在白血病发生中的驱动作用及临床预后价值。
3. **文献名称**: *Immunohistochemical Localization of MYH11 in Vascular Smooth Muscle Cells: Implications for Atherosclerosis*
**作者**: Jones, R.K., et al.
**摘要**: 该文献系统评估了MYH11抗体在动脉粥样硬化模型中对血管平滑肌细胞表型转化的标记效能，发现MYH11表达下调与斑块不稳定性相关，为治疗靶点开发提供依据。
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注：上述文献信息为示例性内容，实际引用时需根据具体研究核实准确性。
The MYH11 antibody targets the protein encoded by the *MYH11* gene, which belongs to the myosin heavy chain family. Myosin heavy chain 11 (MYH11) is a critical component of smooth muscle contractile apparatus, primarily expressed in vascular and visceral smooth muscle cells. It plays a vital role in maintaining vascular tone, peristalsis, and other involuntary muscle functions. The MYH11 protein forms homodimers or heterodimers with other myosin subunits, enabling actin-based motor activity essential for muscle contraction.
In research and diagnostics, the MYH11 antibody is widely used to study smooth muscle differentiation, vascular pathologies, and tumor biology. It serves as a marker for smooth muscle cell identity in immunohistochemistry (IHC), Western blotting, and immunofluorescence (IF). Notably, MYH11 is implicated in specific genetic disorders, such as familial thoracic aortic aneurysms and dissections (TAAD), where mutations in *MYH11* disrupt smooth muscle function. Additionally, MYH11 has gained attention in oncology due to its involvement in chromosomal translocations, particularly the *CBFB-MYH11* fusion gene found in a subset of acute myeloid leukemia (AML) cases. This fusion protein alters transcriptional regulation, contributing to leukemogenesis. The MYH11 antibody aids in detecting such fusion proteins, guiding molecular subtyping and prognosis in AML. Its specificity and reliability make it a valuable tool for both basic research and clinical applications, bridging insights into muscle physiology, genetic diseases, and cancer mechanisms.
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