| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | LGALS8; Galectin-8g; Galectin-8; Po66-CBP; PCTA-1; Gal-8; Galectin 8; PCTA1;;Galectin 8 |
| WB Predicted band size | Calculated MW: 36 kDa ; Observed MW: 40 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Galectin 8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇与Galectin8抗体相关的代表性文献(信息已简化整理)：
1. **文献名称**：Galectin-8 induces functional disease markers in human osteoarthritis and cooperates with galectin-1
**作者**：Bhatia D. et al.
**摘要**：该研究利用特异性抗体检测Galectin8在骨关节炎中的表达，发现其通过调控炎症因子和软骨降解酶，成为潜在的治疗靶点。
2. **文献名称**：Galectin-8 interacts with podoplanin and mediates lymphatic endothelial cell plasticity
**作者**：Cueni L.N. et al.
**摘要**：通过单克隆抗体阻断实验，揭示了Galectin8与podoplanin蛋白互作调控淋巴管生成，为肿瘤转移机制提供了新见解。
3. **文献名称**：Galectin-8 in T cell redox homeostasis: Implications for HIV-1 infection
**作者**：Elahi S. et al.
**摘要**：研究使用中和抗体证实Galectin8通过维持T细胞氧化还原平衡，影响HIV病毒复制，为免疫治疗提供了实验依据。
*注：实际文献检索建议通过PubMed/Google Scholar用关键词"Galectin-8 antibody"+"specific function"获取最新论文，部分研究可能侧重于抗体开发(如：单克隆抗体制备、诊断试剂应用)而非功能研究。*
Galectin-8. a member of the galectin family, is a β-galactoside-binding lectin involved in diverse cellular processes, including immune regulation, autophagy, and cell adhesion. It contains two carbohydrate recognition domains (CRDs) with distinct binding preferences, enabling interactions with glycoproteins and glycolipids. Primarily expressed intracellularly, Galectin-8 also localizes to the extracellular matrix, where it modulates cell signaling and pathogen recognition. Its role in autophagy, particularly in targeting damaged lysosomes (a process termed "galectin-directed autophagy"), has drawn significant attention. Additionally, Galectin-8 functions as a danger sensor, promoting inflammation by activating innate immune pathways like the NLRP3 inflammasome.
Antibodies targeting Galectin-8 are critical tools for studying its biological functions and therapeutic potential. They enable detection of Galectin-8 expression in tissues, cell lines, and pathological conditions such as cancer, autoimmune diseases, and infections. Some studies suggest Galectin-8 overexpression correlates with tumor progression, making it a potential biomarker or therapeutic target. Neutralizing antibodies are being explored to inhibit Galectin-8-mediated pathways in inflammatory diseases or to enhance immune responses in cancer immunotherapy. Challenges remain in optimizing specificity due to structural similarities among galectins. Current research focuses on developing monoclonal antibodies with high affinity and minimal cross-reactivity, advancing both diagnostic and therapeutic applications.
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