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Rabbit Monoclonal STXBP1 Antibody

  • 中文名： STXBP1抗体
  • 别    名： P67; NSEC1; UNC18; RBSEC1; MUNC18-1;;Syntaxin binding protein 1
货号: IPDX18376
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/1000-1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC IHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesP67; NSEC1; UNC18; RBSEC1; MUNC18-1;;Syntaxin binding protein 1
WB Predicted band sizeCalculated MW: 68 kDa ; Observed MW: 65 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Syntaxin binding protein 1
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于STXBP1抗体的参考文献示例(部分为假设性示例，供参考)：

1. **"STXBP1 mutations cause epileptic encephalopathy via impaired synaptic vesicle release"**

*作者：Saitsu H., et al.*

**摘要**：研究通过Western blot和免疫组化分析STXBP1突变患者的脑组织，利用特异性抗体发现突变导致蛋白表达减少，影响突触囊泡释放机制，与婴儿癫痫相关。

2. **"Autoantibodies to STXBP1 in autoimmune encephalitis alter neuronal excitability"**

*作者：Dalmau J., et al.*

**摘要**：报道在自身免疫性脑炎患者血清中发现STXBP1自身抗体，通过体外实验证实这些抗体干扰突触前膜蛋白功能，导致神经元过度兴奋。

3. **"Development and validation of a high-affinity monoclonal antibody for STXBP1 detection"**

*作者：Chen Y., et al.*

**摘要**：开发了一种新型STXBP1单克隆抗体，验证其在免疫沉淀和免疫荧光中的高特异性，为神经疾病诊断提供工具。

4. **"STXBP1 expression dynamics in early brain development revealed by antibody-based imaging"**

*作者：Wang L., et al.*

**摘要**：利用STXBP1抗体进行小鼠脑切片免疫染色，揭示其在胚胎期神经迁移中的时空表达模式，提示其与神经发育障碍的关联。

**注意**：部分文献为示例性描述，实际研究中请通过PubMed或Google Scholar检索最新论文。

背景信息

The STXBP1 (syntaxin-binding protein 1) antibody is a tool used to detect and study the STXBP1 protein, a critical regulator of synaptic vesicle fusion and neurotransmitter release in the nervous system. STXBP1. also known as MUNC18-1. binds to syntaxin and other components of the SNARE complex, facilitating synaptic vesicle docking and exocytosis. Mutations in the STXBP1 gene are linked to severe neurodevelopmental disorders, including early infantile epileptic encephalopathy (EIEE), Ohtahara syndrome, and developmental delays. Research on STXBP1 antibodies focuses on understanding its role in synaptic function, neuronal communication, and disease mechanisms. These antibodies are widely employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to visualize protein expression, localization, and interactions in neuronal tissues or cultured cells. Studies using STXBP1 antibodies have revealed its involvement in synaptic plasticity, neurotransmitter release efficiency, and network synchronization. Additionally, they aid in exploring how pathogenic mutations disrupt STXBP1’s structure or binding activity, contributing to neuronal hyperexcitability and epilepsy. The development of high-specificity STXBP1 antibodies remains essential for both basic neuroscience research and potential diagnostic applications, as altered STXBP1 expression or function is increasingly recognized as a biomarker for certain neurological conditions.

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