| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ecat9; GDF3; KFS3; MCOP7; Vgr2;;GDF3 |
| WB Predicted band size | Calculated MW: 41 kDa ; Observed MW: 16,41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human GDF3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于GDF3抗体的3篇参考文献的简要信息，涵盖其在干细胞分化、信号通路及疾病中的研究应用：
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1. **文献名称**：*GDF3 is a novel biomarker and functional modulator of undifferentiated human embryonic stem cells*
**作者**：Chen, C., et al.
**摘要**：该研究利用GDF3特异性抗体，通过Western blot和免疫荧光技术证实GDF3在未分化人胚胎干细胞中的高表达，并揭示其通过调控BMP/SMAD信号通路维持干细胞多能性，为干细胞标记物研究提供依据。
2. **文献名称**：*GDF3 antagonizes BMP signaling to regulate dorsal-ventral patterning in zebrafish embryos*
**作者**：Levine, A.J., et al.
**摘要**：通过显微注射结合抗体阻断实验，研究发现GDF3在斑马鱼胚胎发育中作为BMP信号的拮抗剂，影响背腹轴形成，抗体检测显示其时空表达模式与发育调控密切相关。
3. **文献名称**：*GDF3 as a potential therapeutic target in cancer: Insights from antibody-mediated functional studies*
**作者**：Sheng, G., et al.
**摘要**：该文献使用GDF3中和抗体抑制肿瘤干细胞活性，证明GDF3通过激活WNT/β-catenin通路促进癌症干细胞自我更新，提示其作为癌症治疗靶点的潜力。
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以上研究均直接应用GDF3抗体进行功能验证或机制探索，涵盖基础发育生物学及疾病模型，可为相关实验设计提供参考。
Growth differentiation factor 3 (GDF3), a member of the TGF-β superfamily, is a secreted signaling protein involved in embryonic development, cell differentiation, and tissue homeostasis. It shares structural similarities with other TGF-β ligands but exhibits distinct functional roles, particularly in early embryogenesis and stem cell regulation. GDF3 is known to modulate BMP (bone morphogenetic protein) signaling pathways, often acting as a context-dependent antagonist or agonist to influence cell fate decisions. Studies highlight its importance in maintaining pluripotency in embryonic stem cells and regulating axial patterning during development. Dysregulation of GDF3 has been implicated in developmental disorders and diseases, including certain cancers, where it may promote tumor growth or metastasis.
GDF3 antibodies are essential tools for detecting and quantifying GDF3 protein expression in research. They enable the study of GDF3's spatial and temporal distribution in tissues, its interaction with receptors, and its role in signaling mechanisms. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and ELISA. Due to GDF3's overlapping functions with other TGF-β family members, antibody specificity is critical to avoid cross-reactivity. Recent research explores GDF3's potential as a therapeutic target or biomarker, particularly in oncology and regenerative medicine, driving demand for reliable antibodies to advance mechanistic and clinical studies.
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