| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Fos L2; Fosl2; FRA 2;;FRA2 |
| WB Predicted band size | Calculated MW: 35 kDa ; Observed MW: 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human FRA2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于FRA2(FOSL2)抗体的3篇参考文献的简要总结：
1. **文献名称**：*"FRA2 expression and its role in fibrosis-related gene transcription"*
**作者**：Smith J, et al.
**摘要**：该研究利用FRA2抗体进行染色质免疫沉淀(ChIP)实验，发现FRA2蛋白通过结合胶原蛋白基因启动子区调控纤维化过程，为肺纤维化治疗提供潜在靶点。
2. **文献名称**：*"Antibody validation for FRA2 in immunohistochemical analysis of tumor tissues"*
**作者**：Lee S, et al.
**摘要**：作者验证了FRA2抗体的特异性，发现其在多种肿瘤组织中高表达，且与癌症侵袭性相关，提示FRA2可能作为肿瘤预后标志物。
3. **文献名称**：*"FOSL2/FRA2 regulates angiogenesis through VEGF signaling pathway"*
**作者**：Wang Y, et al.
**摘要**：通过FRA2抗体阻断实验，研究证实FRA2通过调控血管内皮生长因子(VEGF)的表达促进血管生成，影响肿瘤微环境。
**备注**：以上文献信息为模拟示例，实际引用时需通过PubMed或Web of Science等平台检索真实文献(FRA2相关研究多集中于肿瘤、纤维化及发育生物学领域)。
The FRA2 antibody targets FOS-related antigen 2 (Fra-2), a member of the FOS protein family, which includes c-Fos, Fra-1. and FosB. Fra-2 forms heterodimers with JUN family proteins to create the activator protein 1 (AP-1) transcription factor complex. AP-1 regulates genes involved in cell proliferation, differentiation, apoptosis, and stress responses. Unlike other FOS proteins, Fra-2 exhibits distinct regulatory mechanisms and tissue-specific roles. It is constitutively expressed in certain tissues, such as immune cells and epithelial tissues, and plays critical roles in embryonic development, bone homeostasis, and angiogenesis. Dysregulation of Fra-2 is implicated in pathological conditions, including cancer metastasis, fibrosis, and autoimmune diseases.
The FRA2 antibody is widely used in research to detect Fra-2 expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It aids in studying Fra-2’s role in tumor progression, epithelial-mesenchymal transition (EMT), and inflammatory pathways. Studies highlight its involvement in modulating extracellular matrix remodeling and immune responses, making it a potential therapeutic target. Commercial FRA2 antibodies are typically validated for specificity across human, mouse, and rat samples, with applications in both basic research and clinical biomarker discovery. Understanding Fra-2’s dual roles in homeostasis and disease underscores its importance in cellular signaling research.
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