| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | p40; RAB9p40; RABEPK; RGD1310612; RP11 65N13.1; RP23-446N16.2;;RabEPK |
| WB Predicted band size | Calculated MW: 41 kDa ; Observed MW: 47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human RabEPK |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于p40抗体的参考文献及其摘要概括：
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1. **文献名称**：*ΔNp63 (p40) expression in lung adenocarcinomas and squamous cell carcinomas*
**作者**：Hwang et al. (2011)
**摘要**：该研究验证p40抗体作为鳞状细胞癌特异性标志物的可靠性，发现其在肺鳞癌中高表达，而在腺癌中阴性，支持其用于肺癌亚型鉴别诊断。
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2. **文献名称**：*p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma*
**作者**：Bishop et al. (2012)
**摘要**：比较p40与p63抗体在肺鳞癌诊断中的特异性，证实p40对鳞状分化的标记更具特异性，减少腺癌交叉反应，推荐作为常规免疫组化指标。
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3. **文献名称**：*Utility of p40 in the differential diagnosis of head and neck tumors*
**作者**：Dogan et al. (2012)
**摘要**：评估p40抗体在头颈部肿瘤诊断中的作用，发现其能有效区分鳞癌与淋巴瘤或转移性癌，优化病理诊断流程。
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**备注**：以上文献信息基于领域内经典研究概括，具体引用时请核对原文准确性。
The p40 antibody, also known as ΔNp63. is a nuclear protein encoded by the TP63 gene, a member of the p53 tumor suppressor family. It specifically targets the N-terminally truncated isoform of p63. lacking the transactivation (TA) domain found in full-length TAp63. p63 plays critical roles in epithelial development, differentiation, and stem cell maintenance. The p40 isoform is predominantly expressed in basal and myoepithelial cells of stratified and glandular epithelia, making it a valuable marker in diagnostic pathology.
In clinical practice, p40 is widely used as an immunohistochemical (IHC) marker to distinguish squamous cell carcinoma (SCC) from other malignancies, particularly adenocarcinoma. For example, in lung cancer diagnostics, p40 positivity strongly supports a diagnosis of lung SCC, while adenocarcinomas are typically negative. Its specificity surpasses that of p63. another p63 isoform, which may cross-react with other p63 variants or neoplasms.
The antibody’s utility extends beyond pulmonary pathology, aiding in the identification of SCCs in head and neck, cervical, and esophageal cancers. Recent studies also explore its role in characterizing basal-like breast cancers and thymic tumors. Despite its diagnostic value, interpretation requires caution, as rare adenocarcinomas or neuroendocrine tumors may show focal positivity. Clone-specific variations (e.g., BC28) and standardized protocols are essential for consistent results. Overall, p40 remains a cornerstone in precise tumor subtyping and treatment planning.
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