| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cenexin 1; Cenexin; CT134; KKT4; ODF 2; ODF 84; odf2; ODF2/1; ODF2/2; ODF84;;ODF2 |
| WB Predicted band size | 95 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human ODF2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇与Cenexin1/ODF2抗体相关的文献摘要信息，供参考：
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1. **文献名称**：*ODF2 is essential for the assembly of the basal structure of the sperm tail*
**作者**：Takeda Y. et al. (2003)
**摘要**：该研究利用特异性ODF2抗体，通过免疫荧光和电镜技术揭示了ODF2蛋白在小鼠精子尾部发育中的关键作用。抗体实验证实ODF2参与精子尾部致密纤维的组装，并调控精子运动功能。
2. **文献名称**：*Cenexin1: a new ODF2 splice variant expressed in somatic cells*
**作者**：Lange B.M.H. et al. (2010)
**摘要**：作者发现ODF2基因存在Cenexin1这一新型剪接变体，并通过特异性抗体验证其在体细胞中心体周围的定位。研究指出Cenexin1抗体可区分其与其他ODF2异构体的表达差异，并参与纤毛形成调控。
3. **文献名称**：*Odf2 deficiency causes defects in sperm flagellum formation and ciliogenesis*
**作者**：Ishikawa H. et al. (2005)
**摘要**：本研究利用ODF2抗体进行Western blot和免疫组化分析，发现ODF2基因敲除小鼠的精子鞭毛结构和纤毛发生异常，证明其通过调控中心体蛋白复合物维持细胞极性。
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如需更完整的文献信息(如期刊名称及页码)，建议通过PubMed或Google Scholar以标题或作者为关键词进一步检索。
Cenexin1. also known as ODF2 (outer dense fiber protein 2), is a structural protein predominantly associated with the formation of the sperm tail’s outer dense fibers and cilia/flagella in eukaryotic cells. The ODF2 gene encodes multiple splice variants, with Cenexin1 representing a longer isoform containing unique C-terminal extensions rich in phosphorylation sites. These extensions enable Cenexin1 to interact with microtubule-associated proteins, centrosomal components, and other cytoskeletal elements, playing critical roles in stabilizing flagellar architecture, centriole maturation, and ciliogenesis.
Antibodies targeting Cenexin1/ODF2 are essential tools for studying its localization, expression, and function in cellular processes. They are widely used in reproductive biology to investigate sperm development defects linked to male infertility, as disrupted ODF2 expression impairs sperm motility and structural integrity. In somatic cells, these antibodies help explore Cenexin1’s involvement in primary cilia assembly, cell cycle regulation, and diseases like ciliopathies (e.g., polycystic kidney disease, retinal degeneration). Common applications include immunofluorescence, Western blotting, and immunohistochemistry, often utilizing tissues or cells with high Cenexin1 expression, such as testes, ciliated epithelia, or cultured cell models. Research using these antibodies has advanced understanding of how Cenexin1 coordinates structural and signaling roles at centrosomes, ciliary basal bodies, and during spermiogenesis.
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