| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | LOQS; Prbp; tarbp2; TRBP; TRBP1; TRBP2;;TARBP2 |
| WB Predicted band size | 39 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human TARBP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于TRBP抗体的3篇参考文献示例(注：文献信息为模拟示例，非真实存在，仅供参考)：
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1. **Lee, Y. et al. (2016).**
*"TRBP Antibody-Based Detection of RNA-Protein Interactions in HIV-1 Replication."*
**摘要**：本研究利用TRBP特异性抗体，通过免疫沉淀和RNA测序技术，揭示了TRBP在HIV-1病毒RNA包装和翻译中的关键作用，证明其通过结合病毒TAR RNA促进病毒复制。
2. **Smith, J. & Garcia, M.A. (2018).**
*"Characterization of TRBP Isoforms Using Monoclonal Antibodies in Neurodegenerative Disease Models."*
**摘要**：作者开发了针对TRBP不同亚型的单克隆抗体，验证了其在Western blot和免疫荧光中的特异性，并发现TRBP-2在阿尔茨海默病模型中与Ago2的相互作用异常增强。
3. **Chen, L. et al. (2020).**
*"TRBP Antibody Reveals Its Role in Modulating miRNA Biogenesis via Dicer Interaction."*
**摘要**：通过TRBP抗体介导的免疫共沉淀实验，证实TRBP与Dicer复合物结合并调控miRNA成熟过程，影响下游基因沉默功能，为癌症中miRNA失调提供了机制解释。
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**注**：以上文献为假设性示例，实际引用时请通过学术数据库(如PubMed、Web of Science)检索真实文献。若需具体文献协助，建议提供更详细的研究背景。
TRBP (TAR RNA-binding protein), also known as TARBP2. is a double-stranded RNA-binding protein encoded by the TARBP2 gene. It plays critical roles in RNA interference (RNAi) pathways, microRNA (miRNA) processing, and post-transcriptional gene regulation. TRBP interacts with Dicer, a key enzyme in the RNAi machinery, to facilitate the processing of precursor miRNAs into mature miRNAs, which are essential for gene silencing. Additionally, TRBP is involved in HIV-1 replication by binding to the viral TAR RNA element, modulating viral transcription and evasion of host immune responses.
TRBP antibodies are essential tools for studying its molecular functions, protein-protein interactions, and subcellular localization. These antibodies are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect TRBP expression in various cell types and tissues. Dysregulation of TRBP has been linked to cancers, neurological disorders, and viral infections, making its detection crucial for understanding disease mechanisms. For instance, altered TRBP levels are observed in glioblastoma, colorectal cancer, and HIV-associated pathologies. Researchers also utilize TRBP antibodies to explore its role in stress granule formation, autophagy, and antiviral defense pathways. Commercial TRBP antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated knockdown. Their applications extend to diagnostic research and therapeutic development, particularly in targeting RNAi pathways or viral replication processes.
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