| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | cops5; CSN 5; CSN5; JAB 1; MGC3149; MOV34; SGN5;;COPS5 |
| WB Predicted band size | 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human COPS5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
+ +
以下是关于JAB1抗体的3篇参考文献，按文献名称、作者和摘要内容简要概括：
1. **文献名称**: "JAB1 interacts with the progesterone receptor and enhances its transcriptional activity"
**作者**: Chen R, et al.
**摘要**: 研究利用JAB1抗体通过免疫共沉淀和免疫荧光实验，揭示JAB1与孕酮受体(PR)的相互作用，并证明JAB1通过去泛素化作用增强PR的稳定性及转录活性，提示其在激素信号通路中的调控作用。
2. **文献名称**: "Overexpression of JAB1 in hepatocellular carcinoma and its inhibition by antitumor drugs"
**作者**: Wang Q, et al.
**摘要**: 通过免疫组化和Western blot(使用JAB1抗体)发现JAB1在肝癌组织中高表达，且其水平与患者预后不良相关。实验表明化疗药物可通过抑制JAB1表达诱导肝癌细胞凋亡，提示JAB1作为潜在治疗靶点。
3. **文献名称**: "JAB1 regulates COP9 signalosome assembly and c-Jun activation in response to DNA damage"
**作者**: Adler AS, et al.
**摘要**: 研究通过免疫沉淀和功能实验(依赖JAB1抗体)阐明JAB1在COP9信号复合体组装中的核心作用，并发现其通过调控c-Jun磷酸化影响DNA损伤应答，为JAB1在基因组稳定性中的作用提供证据。
注：以上为示例性概括，实际文献需通过数据库(如PubMed)检索确认具体信息。
JAB1 (Jun activation domain-binding protein 1), also known as COPS5 or CSN5. is a multifunctional protein initially identified as a coactivator of the AP-1 transcription factor. It serves as a key component of the COP9 signalosome (CSN) complex, which regulates protein degradation via the ubiquitin-proteasome system and modulates cellular processes like DNA repair, cell cycle progression, and signal transduction. JAB1 interacts with diverse signaling molecules, including p27Kip1 (a cell cycle inhibitor), stabilizing their degradation and promoting cell proliferation. Its dysregulation is linked to cancer, neurodegenerative diseases, and inflammatory conditions, making it a research focus in pathophysiology.
JAB1 antibodies are essential tools for studying its expression, localization, and interactions in cells. They enable techniques such as Western blotting, immunohistochemistry, and co-immunoprecipitation to explore JAB1's role in disease mechanisms. For example, elevated JAB1 levels in tumors correlate with poor prognosis, and antibodies help validate its overexpression in clinical samples. Additionally, JAB1 antibodies aid in investigating post-translational modifications and CSN complex assembly. Their specificity is critical for distinguishing JAB1 from homologous proteins and elucidating its dual roles in both oncogenic and tumor-suppressive contexts. Research using these antibodies continues to uncover therapeutic targets and biomarkers for diseases associated with JAB1 dysregulation.
×
