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Rabbit Monoclonal MT-ND1 Antibody

  • 中文名： MT-ND1抗体
  • 别    名： MT-ND1; MTND1; NAD1; NADH1; ND1;;MT ND1
货号: IPDX18132
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesMT-ND1; MTND1; NAD1; NADH1; ND1;;MT ND1
WB Predicted band sizeCalculated MW: 36 kDa ; Observed MW: 38 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human MT ND1
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于MT-ND1抗体的3篇参考文献的简要列举(注：以下内容为示例性模拟，实际文献需通过学术数据库查询)：

1. **文献名称**：*MT-ND1 mutations impair mitochondrial complex I assembly and neurodevelopment*

**作者**：Smith A, et al.

**摘要**：研究利用MT-ND1抗体通过Western blot和免疫荧光技术，发现特定突变导致线粒体复合物I组装异常，与儿童神经发育障碍相关，提示MT-ND1蛋白稳定性对线粒体功能至关重要。

2. **文献名称**：*Autoantibodies against MT-ND1 in autoimmune encephalitis: diagnostic and functional insights*

**作者**：Chen L, et al.

**摘要**：该文献报道了一种针对MT-ND1的自身抗体在自身免疫性脑炎患者中的发现，通过ELISA和免疫组化验证抗体的特异性，并探讨其可能干扰线粒体能量代谢的病理机制。

3. **文献名称**：*MT-ND1 expression profiling in colorectal cancer: correlation with oxidative stress markers*

**作者**：Wang Y, et al.

**摘要**：研究使用MT-ND1抗体分析结直肠癌组织中线粒体ND1蛋白表达水平，发现其下调与氧化应激标志物升高相关，提示MT-ND1可能在肿瘤代谢重编程中起调控作用。

如需具体文献，建议通过PubMed或Google Scholar检索关键词“MT-ND1 antibody”或结合研究领域(如疾病名称+MT-ND1)进一步筛选。

背景信息

The MT-ND1 antibody targets the MT-ND1 protein (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1), a critical component of mitochondrial complex I in the electron transport chain. Encoded by the mitochondrial ND1 gene, MT-ND1 is essential for oxidative phosphorylation, facilitating proton translocation and ATP production. Mutations in MT-ND1 are linked to mitochondrial disorders, including Leber’s hereditary optic neuropathy (LHON), mitochondrial encephalomyopathy, and Parkinson’s disease, underscoring its role in cellular energy metabolism and disease pathology. MT-ND1 antibodies are widely used in research to study mitochondrial dysfunction, particularly in neurodegeneration, cancer, and aging. These antibodies enable protein detection via techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding in the assessment of complex I assembly and activity. Additionally, they contribute to investigating metabolic adaptations in diseases characterized by oxidative stress. As mitochondrial research advances, MT-ND1 antibodies remain vital tools for exploring the interplay between genetic mutations, bioenergetic failure, and clinical manifestations in mitochondrial disorders.

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