| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GIMPc; golim4; GOLPH 4; GPP130; P 138; P138;;Golgi phosphoprotein 4 |
| WB Predicted band size | Calculated MW: 82 kDa ; Observed MW: 130 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Golgi phosphoprotein 4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于GOLPH4抗体的文献示例(内容为模拟概括，非真实文献)：
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1. **文献名称**：*GOLPH4 regulates Golgi structure and promotes cancer cell invasion*
**作者**：Smith J, et al.
**摘要**：研究利用GOLPH4抗体通过免疫荧光和Western blot，发现GOLPH4通过维持高尔基体结构完整性促进肿瘤细胞迁移和侵袭，其高表达与乳腺癌患者预后不良相关。
2. **文献名称**：*Characterization of a novel monoclonal antibody against human GOLPH4 for diagnostic applications*
**作者**：Lee S, et al.
**摘要**：报道了一种新型GOLPH4单克隆抗体的开发与验证，该抗体在免疫组化中特异性标记高尔基体，可用于胃癌组织中高尔基体形态异常的病理诊断。
3. **文献名称**：*GOLPH4 links the Golgi to exosome secretion and modulates viral replication*
**作者**：Zhang Y, et al.
**摘要**：通过GOLPH4抗体介导的蛋白质敲低实验，揭示GOLPH4通过调控外泌体分泌通路影响丙肝病毒(HCV)的复制，为抗病毒治疗提供新靶点。
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如需真实文献，建议在PubMed或Google Scholar以“GOLPH4 antibody”或“GOLPH4 function”为关键词检索。
GOLPH4. also known as Golgi phosphoprotein 4 or GP73. is a type II transmembrane protein predominantly localized to the Golgi apparatus. It plays a role in maintaining Golgi structure and facilitating vesicular trafficking, though its precise molecular mechanisms remain under investigation. Initially identified as a resident Golgi protein, GOLPH4 gained attention due to its upregulated expression in various pathological conditions, particularly liver diseases and cancers. For example, elevated serum GP73 levels are considered a potential biomarker for hepatocellular carcinoma (HCC) and hepatitis C virus (HCV) infection, offering diagnostic advantages over traditional markers like alpha-fetoprotein (AFP).
GOLPH4 antibodies are essential tools for studying its expression, localization, and function. These antibodies, often monoclonal or polyclonal, enable detection via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Specificity validation, including knockout cell line controls, ensures reliable results. Research using GOLPH4 antibodies has revealed its overexpression in cancers, correlating with tumor progression and metastasis. Additionally, studies explore its role in viral infections, where some viruses exploit Golgi pathways involving GOLPH4. Despite its emerging significance, further work is needed to unravel its full biological relevance and therapeutic potential.
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