| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RGS13; RGS18;;RGS18 |
| WB Predicted band size | 28 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human RGS18 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于RGS18抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*RGS18 regulates platelet activation via selective modulation of G protein signaling*
**作者**：Kim S, et al.
**摘要**：研究通过特异性RGS18抗体发现，RGS18通过抑制Gαq和Gα13信号通路调控血小板活化，并影响血栓形成过程。
2. **文献名称**：*RGS18 is a key regulator of megakaryocyte differentiation*
**作者**：Garcia-Bernal D, et al.
**摘要**：利用RGS18抗体和siRNA技术，发现RGS18通过调节MAPK通路影响巨核细胞分化，并可能参与骨髓纤维化病理机制。
3. **文献名称**：*RGS proteins in cancer: Role of RGS18 in tumor progression*
**作者**：Wang L, et al.
**摘要**：通过免疫组化分析(使用RGS18抗体)，发现RGS18在结肠癌组织中表达下调，可能与肿瘤细胞增殖和转移抑制相关。
4. **文献名称**：*Post-translational modification of RGS18 determines its subcellular localization*
**作者**：Zhang Y, et al.
**摘要**：研究利用RGS18特异性抗体揭示其磷酸化修饰调控核质穿梭，进而影响巨核细胞成熟和血小板生成。
(注：以上文献信息为模拟示例，实际引用需查询具体数据库。)
The Regulator of G-protein Signaling 18 (RGS18) is a member of the RGS protein family, which modulates G-protein-coupled receptor (GPCR) signaling by enhancing the GTPase activity of Gα subunits, thereby terminating downstream signaling. RGS18 is particularly enriched in platelets, megakaryocytes, and certain immune cells, where it plays critical roles in regulating cellular responses to stimuli like thrombin, ADP, and chemokines. Its expression is tightly controlled during hematopoiesis and thrombopoiesis, implicating it in hemostasis, thrombosis, and inflammation. Dysregulation of RGS18 has been linked to platelet hyperactivity, bleeding disorders, and hematologic malignancies.
RGS18 antibodies are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies enable detection via techniques such as Western blotting, immunohistochemistry, and flow cytometry, aiding research on RGS18's interaction networks and regulatory mechanisms. Commercially available RGS18 antibodies are typically developed against specific epitopes (e.g., N-terminal or C-terminal regions) and validated for cross-reactivity in human, mouse, or rat models. Their applications extend to exploring RGS18's potential as a therapeutic target, particularly in cardiovascular diseases and cancer, where GPCR signaling pathways are often aberrant. Ongoing studies focus on elucidating RGS18's role in platelet inhibition and its crosstalk with other signaling molecules.
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