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Rabbit Monoclonal TRAF6BP Antibody

  • 中文名： TRAF6BP抗体
  • 别    名： CALCOCO3; D6Ertd404e; D6Ertd772e; PRO0105; T6BP; TAX1BP1; tax1bp1b; TXBP151;;Tax1 binding protein 1
货号: IPDX18122
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCALCOCO3; D6Ertd404e; D6Ertd772e; PRO0105; T6BP; TAX1BP1; tax1bp1b; TXBP151;;Tax1 binding protein 1
WB Predicted band size91 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Tax1 binding protein 1
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于TRAF6BP抗体的3篇文献示例(内容为模拟概括，仅供参考)：

1. **"TRAF6BP regulates TLR4-mediated NF-κB signaling through interaction with TRAF6"**

*作者：Li X, et al.*

**摘要**：研究利用TRAF6BP特异性抗体，通过免疫共沉淀验证了TRAF6BP与TRAF6在TLR4信号通路中的直接相互作用，证明其通过调控K63泛素化促进NF-κB激活。

2. **"Antibody-based profiling of TRAF6BP in autoimmune disorders"**

*作者：Chen R, et al.*

**摘要**：开发了一种高特异性TRAF6BP单克隆抗体，用于检测类风湿性关节炎患者样本中TRAF6BP的异常表达，揭示其与炎症因子IL-6的正相关性。

3. **"TRAF6BP mediates crosstalk between autophagy and innate immunity"**

*作者：Wang Y, et al.*

**摘要**：通过Western blot和免疫荧光技术(使用TRAF6BP抗体)，发现TRAF6BP通过结合Beclin-1调控自噬体形成，并影响病毒诱导的干扰素信号通路。

注：以上文献名为虚构示例，实际研究中建议通过PubMed或Google Scholar以“TRAF6BP antibody”或“TRAF6-binding protein antibody”为关键词检索最新文献。

背景信息

The TRAF6BP (TRAF6 Binding Protein) antibody is a research tool used to study the protein encoded by the *TRAF6BP* gene, also known as *T6BP* or *MAP3K7IP3*. TRAF6BP interacts with TRAF6 (TNF Receptor-Associated Factor 6), a key adaptor protein in signaling pathways mediated by Toll-like receptors (TLRs), interleukin-1 receptors (IL-1Rs), and the TNF superfamily. TRAF6BP regulates TRAF6 ubiquitination and downstream activation of NF-κB and MAPK signaling cascades, which are critical for immune responses, inflammation, and cell survival. The antibody is commonly used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect TRAF6BP expression, localization, and interactions in various cell types or tissues. It helps researchers investigate the protein's role in physiological processes, such as innate immunity and osteoclastogenesis, as well as pathological conditions, including cancer, autoimmune diseases, and infections. TRAF6BP antibodies are typically generated in rabbits or mice using immunogenic peptide sequences specific to the protein. Validation often includes knockout/knockdown controls to confirm specificity. Its application contributes to understanding TRAF6BP's regulatory mechanisms in TRAF6-dependent signaling and potential therapeutic targeting of related pathways.

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