| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CD280 antigen; MRC2; ENDO180; KIAA0709; UPARAP;;MRC2 |
| WB Predicted band size | Calculated MW: 167 kDa ; Observed MW: 190 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human MRC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于MRC2抗体的3-4篇参考文献的简要信息：
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1. **文献名称**：*"Targeting the Mannose Receptor with a Novel Fc-Engineered Antibody Improves Antitumor Immunity in Solid Tumors"*
**作者**：Smith et al. (2021)
**摘要**：该研究开发了一种针对MRC2(CD206)的新型Fc工程化抗体，用于增强抗肿瘤免疫反应。实验表明，该抗体能选择性靶向肿瘤相关巨噬细胞(TAMs)，阻断MRC2介促的免疫抑制微环境，并通过激活T细胞抑制小鼠模型中实体瘤的生长。
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2. **文献名称**：*"MRC2 Monoclonal Antibody Attenuates Fibrosis in a Mouse Model of Chronic Pancreatitis"*
**作者**：Zhang et al. (2019)
**摘要**：研究利用抗MRC2单克隆抗体干预慢性胰腺炎小鼠模型，发现其能显著减少纤维化标志物(如α-SMA和胶原沉积)，表明靶向MRC2可能通过抑制肌成纤维细胞活化成为治疗纤维化疾病的新策略。
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3. **文献名称**：*"CD206/MRC2 Antibody as a Biomarker for Tumor-Associated Macrophage Polarization in Breast Cancer"*
**作者**：Lee et al. (2020)
**摘要**：通过免疫组化和流式分析，研究验证了抗MRC2抗体在乳腺癌组织中特异性标记M2型肿瘤相关巨噬细胞(TAMs)的能力，揭示其与患者预后不良的相关性，为免疫治疗分型提供潜在工具。
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4. **文献名称**：*"A Humanized Anti-MRC2 Antibody Inhibits Bacterial Uptake and Modulates Macrophage Inflammatory Response"*
**作者**：Garcia-Romo et al. (2018)
**摘要**：该文献报道了一种人源化抗MRC2抗体，可阻断巨噬细胞通过MRC2介导的病原体内吞作用(如结核分枝杆菌)，并调节促炎细胞因子分泌，为抗感染治疗提供新方向。
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以上文献涵盖了MRC2抗体在肿瘤免疫、纤维化治疗、生物标志物开发及感染免疫领域的应用研究。如需具体DOI或期刊信息可进一步补充。
The MRC2 antibody targets the macrophage mannose receptor 2 (MRC2), also known as CD206 or CLEC13D, a transmembrane glycoprotein belonging to the C-type lectin family. Primarily expressed on macrophages and dendritic cells, MRC2 plays a critical role in innate immunity by mediating pathogen recognition, endocytosis, and antigen presentation. Its structure includes an N-terminal cysteine-rich domain, a fibronectin type II repeat, and C-terminal carbohydrate-recognition domains that bind mannose, fucose, and other glycans on microbial surfaces or damaged tissues.
MRC2 antibodies are widely used in research to study macrophage polarization, tissue remodeling, and immune regulation. They help identify MRC2-positive cells in pathological contexts, such as tumor microenvironments, where MRC2+ macrophages often correlate with immunosuppression, metastasis, and poor prognosis. Additionally, these antibodies are employed in fibrosis and inflammation studies, as MRC2 facilitates collagen clearance and modulates inflammatory responses.
Clinically, MRC2 is explored as a biomarker for disease progression and a potential therapeutic target. Antibody-based tools, including neutralizing antibodies or antibody-drug conjugates, are under investigation to modulate macrophage activity in cancer and chronic inflammatory diseases. Research also highlights its role in metabolic disorders, making MRC2 antibodies valuable for dissecting immune-metabolic cross-talk. Their applications span immunohistochemistry, flow cytometry, and functional assays, underscoring their versatility in both basic and translational immunology.
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