| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CAS2; CATB; GP75; OCA3; TRP1;TYRP; TYRP1; TYRRP;;TRP1 |
| WB Predicted band size | 61 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human TRP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于TRP1抗体的模拟参考文献示例(均为虚构，仅供格式参考)：
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1. **文献名称**: *Monoclonal Antibody Targeting TRP1 in Melanoma Diagnosis*
**作者**: Smith A, et al.
**摘要**: 研究开发了一种针对TRP1的单克隆抗体，通过免疫组化分析其在黑色素瘤组织中的表达。结果显示TRP1抗体在转移性黑色素瘤中敏感性达85%，提示其作为辅助诊断工具的潜力。
2. **文献名称**: *TRP1 Autoantibodies in Vitiligo Pathogenesis*
**作者**: Chen L, et al.
**摘要**: 探讨白癜风患者血清中TRP1自身抗体的存在及其与疾病进展的关联。ELISA检测发现60%活动期患者抗体水平升高，提示TRP1可能作为自身免疫反应的靶点。
3. **文献名称**: *Structural Characterization of TRP1 Epitopes via Phage Display*
**作者**: Gupta R, et al.
**摘要**: 利用噬菌体展示技术鉴定TRP1的线性表位，发现C端区域是抗体结合的关键位点，为开发靶向黑色素生成的治疗性抗体提供依据。
4. **文献名称**: *TRP1 Antibody-mediated Inhibition of Melanin Synthesis*
**作者**: Tanaka K, et al.
**摘要**: 体外实验表明，抗TRP1抗体可通过阻断酶活性抑制黑色素生成，提示其在色素沉着疾病中的潜在治疗应用。
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**注意**：以上文献及摘要均为模拟创作，真实文献请通过PubMed、Google Scholar等平台检索关键词“TRP1 antibody”或“TYRP1 antibody”获取。
**Background of TRP1 Antibody**
TRP1 (Tyrosinase-Related Protein 1), encoded by the *TYRP1* gene, is a melanocyte-specific enzyme integral to melanin synthesis. It functions alongside tyrosinase (TYR) and TRP2 (DCT) in the melanogenic pathway, primarily stabilizing the tyrosinase enzyme complex and modulating the oxidation of intermediates to produce eumelanin (brown/black pigments). TRP1 is also known as gp75. a glycoprotein localized in melanosomes, and its mutations are linked to oculocutaneous albinism type 3 (OCA3) and pigmentary disorders.
TRP1 antibodies are tools used to study melanogenesis, melanocyte biology, and diseases like melanoma and vitiligo. In melanoma research, TRP1 antibodies help detect protein expression levels, aiding in tumor characterization and therapeutic targeting. In vitiligo, TRP1 serves as an autoantigen, and antibodies against it are implicated in autoimmune melanocyte destruction. These antibodies are employed in techniques such as Western blotting, immunohistochemistry, and flow cytometry to analyze TRP1 expression in cells and tissues.
Commercial TRP1 antibodies are typically monoclonal or polyclonal, with specificity validated across human and murine models. Their applications extend to dermatology, oncology, and genetic research, providing insights into pigmentary mechanisms and potential therapeutic strategies. However, cross-reactivity with related proteins (e.g., TRP2) requires careful validation to ensure experimental accuracy.
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