| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | OP-1 |
| Entrez GeneID | 655 |
| clone | 6E5D12 |
| WB Predicted band size | 49.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Purified recombinant fragment of human BMP7 (AA: 239-431) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇与β-casein抗体相关的研究文献概览，供参考：
1. **《Antibodies to bovine beta-casein in diabetes and other autoimmune diseases》**
Authors: Elliott RB et al.
摘要：该研究检测了1型糖尿病及其他自身免疫疾病患者血清中抗A1 β-casein抗体的水平，发现其浓度显著高于健康人群，提示A1型β-casein可能通过分子模拟机制触发自身免疫反应。
2. **《Comparative effects of A1 versus A2 beta-casein on gastrointestinal motility and inflammatory markers》**
Authors: Jianqin S et al.
摘要：通过双盲试验比较A1与A2型β-casein对消化系统的影响，发现摄入A1型可增加肠道炎症因子(如IL-4)并诱导特异性IgG抗体升高，可能与乳糖不耐受症状相关。
3. **《Beta-casein antibodies in milk allergy diagnosis》**
Authors: Cafarelli C et al.
摘要：评估β-casein特异性IgE/IgG抗体作为儿童牛奶过敏生物标志物的价值，提出抗体滴度与临床过敏严重程度呈正相关，但需结合其他蛋白(如α-casein)抗体综合诊断。
*注：以上文献为示例性内容，实际引用请核实具体论文数据及来源。建议通过PubMed或Web of Science以“beta-casein antibody”、“A1 milk autoimmunity”等关键词检索近年文献。*
Beta-casein antibodies are immunological tools developed to detect and study beta-casein, a major protein component of milk in mammals, particularly cows. As one of the four primary casein proteins, beta-casein exists in several genetic variants, with A1 and A2 being the most studied. These variants differ by a single amino acid substitution, which influences the release of bioactive peptides like beta-casomorphin-7 (BCM-7) during digestion. Antibodies targeting beta-casein are typically generated in laboratory animals (e.g., rabbits, mice) using purified beta-casein as an antigen. They enable the identification and quantification of beta-casein in dairy products, research on milk protein metabolism, and investigations into potential health effects linked to A1 beta-casein consumption, such as digestive discomfort or inflammatory responses.
These antibodies are widely used in immunoassays (ELISA, Western blot) to assess milk quality, allergen content, or A1/A2 protein ratios in commercial dairy. Additionally, they support studies exploring the role of beta-casein in conditions like lactose intolerance or autoimmune disorders. Recent interest in A2 milk (containing only A2 beta-casein) has further driven demand for specific antibodies to differentiate variants. However, cross-reactivity between similar casein proteins requires careful validation to ensure accuracy. Overall, beta-casein antibodies serve as critical reagents in both food science and biomedical research, bridging gaps between dairy chemistry and human health.
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