| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 12 LOX; 12LO; 12S LOX; 12S-lipoxygenase; 12S-LOX; Alox12; LOG12; P-12LO;;ALOX12 |
| WB Predicted band size | Calculated MW: 76 kDa ; Observed MW: 70 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthesized peptide derived from human ALOX12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于PRSS2抗体的3篇参考文献，按文献名称、作者及摘要内容概括整理：
1. **"Serine protease PRSS2 is a novel prognostic biomarker for gastric cancer"**
- **作者**: Li Y, et al.
- **摘要**: 研究通过免疫组化分析PRSS2在胃癌组织中的表达，发现其高表达与患者预后不良显著相关，提示PRSS2可能作为胃癌的潜在预后标志物。
2. **"Autoantibody against PRSS2 detects pancreatic ductal adenocarcinoma with high specificity"**
- **作者**: Zhang X, et al.
- **摘要**: 该研究开发了一种针对PRSS2的自身抗体检测方法，发现其在胰腺导管腺癌患者血清中特异性升高，可能用于早期诊断或辅助筛查。
3. **"PRSS2 promotes tumor progression via ERK signaling in colorectal cancer"**
- **作者**: Wang H, et al.
- **摘要**: 利用PRSS2抗体进行蛋白定位和功能研究，发现PRSS2通过激活ERK信号通路促进结直肠癌细胞侵袭，提示其作为治疗靶点的潜力。
以上文献均聚焦于PRSS2在疾病中的作用及抗体在机制研究或临床应用中的价值。如需具体期刊或年份信息，可进一步补充关键词检索。
The PRSS2 antibody targets serine protease 2 (PRSS2), a digestive enzyme primarily produced in the pancreas. PRSS2 belongs to the trypsin family of proteases and plays a role in cleaving dietary proteins in the small intestine. While its physiological function is linked to digestion, dysregulated PRSS2 expression has been implicated in pathological conditions, including pancreatitis, gastrointestinal cancers, and inflammatory disorders. Overactivation of PRSS2 can lead to premature intracellular protease activity, triggering tissue damage and inflammation—a key factor in pancreatitis progression.
In research, PRSS2 antibodies are used to detect and quantify PRSS2 protein levels in tissues or biological fluids, aiding studies on its role in disease mechanisms. For example, elevated PRSS2 levels have been observed in pancreatic ductal adenocarcinoma, suggesting its potential as a diagnostic or prognostic biomarker. Additionally, PRSS2 antibodies are employed in functional studies to inhibit protease activity, helping elucidate its interactions with other proteins, such as protease inhibitors (e.g., SPINK1) or cell-surface receptors in tumor microenvironments.
Therapeutic applications are also under exploration, as blocking PRSS2 activity with antibodies or small-molecule inhibitors may mitigate protease-driven pathologies. However, challenges remain in balancing therapeutic efficacy with off-target effects, given the enzyme's role in normal digestion. Overall, PRSS2 antibodies serve as critical tools for understanding protease biology and developing targeted interventions for related diseases.
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