| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Dek; DEK oncogene; Protein DEK;;DEK |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthesized peptide derived from human DEK |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
+ +
以下是3篇与DEK抗体相关的研究文献及简要摘要：
1. **《Autoantibodies to DEK oncoprotein in human inflammatory disease》**
- 作者：Dong X, et al.
- 摘要：首次报道DEK蛋白作为系统性红斑狼疮(SLE)患者血清中的自身抗体靶点，发现约10-20%的SLE患者存在抗DEK抗体，提示其可能作为SLE的生物标志物。
2. **《DEK autoantibodies in juvenile idiopathic arthritis》**
- 作者：Salles M, et al.
- 摘要：研究幼年特发性关节炎(JIA)患者中DEK抗体的表达，发现其与疾病活动度相关，可能参与关节滑膜炎症的病理过程。
3. **《The role of anti-DEK antibodies in autoimmune hepatitis》**
- 作者：Terzic T, et al.
- 摘要：探讨DEK抗体在自身免疫性肝炎(AIH)中的临床意义，发现其阳性率显著高于健康对照组，可能与肝组织损伤相关。
4. **《DEK in oncogenesis and autoimmunity: molecular insights》**
- 作者：Waldmann T, et al.
- 摘要：综述DEK蛋白在癌症和自身免疫疾病中的双重作用，提出其通过染色质重塑和炎症通路激活导致抗体产生的分子机制。
注：以上文献信息为示例性质，实际引用需核对原文准确性。建议通过PubMed或Web of Science以"DEK autoantibody"为关键词检索最新研究。
The DEK antibody is an autoantibody targeting the DEK protein, a chromatin-associated factor encoded by the *DEK* gene. DEK is involved in critical nuclear processes, including chromatin remodeling, transcriptional regulation, RNA splicing, and DNA repair. It plays roles in cell differentiation, proliferation, and apoptosis, with dysregulation linked to cancers and autoimmune disorders.
DEK autoantibodies are clinically significant in autoimmune diseases, particularly systemic lupus erythematosus (SLE). First identified in SLE patients, they are detected in 10-30% of cases, often correlating with disease activity, skin manifestations, and renal involvement. DEK antibodies are part of the broader antinuclear antibody (ANA) profile but are less common than anti-dsDNA or anti-Smith antibodies. Their presence is also noted in juvenile SLE and other autoimmune conditions, though with lower prevalence.
The DEK protein’s proinflammatory properties, when released during cell death, may trigger autoantibody production. DEK antibodies are detected via ELISA or immunoblotting, aiding diagnosis and disease monitoring. Research continues to explore their pathogenic role, including potential contributions to tissue damage via immune complex deposition.
While not exclusive to SLE, DEK antibodies serve as biomarkers for specific clinical subsets, highlighting the interplay between autoimmunity and nuclear antigen dysregulation. Their study offers insights into SLE mechanisms and potential therapeutic targets.
×
