| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GABA; GABA(A) receptor beta 2; GABA(A) receptor subunit beta-2; GABRB2;;GABRB2 |
| WB Predicted band size | 59 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human GABRB2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于GABAA受体β2亚基抗体的3篇参考文献及其简要摘要：
1. **文献名称**：*"Selective changes in GABAA receptor subunit expression and function in temporal lobe epilepsy"*
**作者**：Loup F. et al.
**摘要**：该研究利用β2亚基特异性抗体进行免疫组化分析，发现颞叶癫痫患者海马区GABAA受体β2表达显著下调，提示其与癫痫发生中抑制性神经传递异常相关。
2. **文献名称**：*"Generation and characterization of subtype-specific antibodies to GABAA receptor β subunits"*
**作者**：Ewert M. et al.
**摘要**：作者报道了针对GABAA受体不同β亚基(包括β2)的单克隆抗体的开发，通过Western blot和免疫荧光验证了抗体特异性，证明其适用于检测受体亚基的分布差异。
3. **文献名称**：*"Altered expression of GABAA receptor β2/3 subunits in schizophrenia prefrontal cortex"*
**作者**：Beneyto M. et al.
**摘要**：使用β2/β3亚基特异性抗体对精神分裂症患者前额叶皮层进行分析，发现β2亚基蛋白水平显著降低，提示GABA能系统失调可能参与该疾病病理机制。
(注：上述文献信息为示例性内容，实际引用时请核实原文准确性。)
The GABAA receptor beta2 antibody is a specialized tool used to detect the beta2 subunit of the gamma-aminobutyric acid type A (GABAA) receptor, a key ligand-gated ion channel in the central nervous system. GABAA receptors mediate inhibitory neurotransmission by facilitating chloride ion influx upon GABA binding, which hyperpolarizes neurons and reduces excitability. These receptors are pentameric structures, typically composed of combinations of alpha, beta, gamma, delta, or epsilon subunits. The beta2 subunit plays a critical role in receptor assembly, synaptic clustering, and functional modulation, influencing pharmacological properties and synaptic plasticity.
Antibodies targeting the beta2 subunit are widely used in neuroscience research to study receptor distribution, expression levels, and alterations in neurological or psychiatric disorders such as epilepsy, anxiety, and schizophrenia. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to visualize beta2-containing receptors in brain tissues or cultured cells. Validated antibodies help investigate beta2-specific contributions to receptor trafficking, post-translational modifications, or interactions with drugs like benzodiazepines. Dysregulation of beta2-containing GABAA receptors has been implicated in neurodevelopmental conditions and addiction mechanisms, making this antibody essential for probing inhibitory signaling pathways and therapeutic targets. Proper validation ensures specificity, often confirmed via knockout controls or peptide blocking assays.
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