| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AMS2; MAT 2; MAT 2A; MAT II; Mat2a; MATA2; MATII; SAMS 2; SAMS2;;MAT2A |
| WB Predicted band size | Calculated MW: 44 kDa ; Observed MW: 48 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human MAT2A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于MAT2A抗体的3篇文献的简要列举(文献信息为模拟概括，非真实引用)：
1. **"MAT2A as a therapeutic target in MTAP-deficient cancers"**
*Authors: Smith J. et al.*
摘要：研究揭示了MAT2A在MTAP缺失型肿瘤中的关键作用，利用MAT2A抗体验证了其在癌细胞系中的蛋白表达上调，并证明其抑制剂可诱导合成致死效应。
2. **"Regulation of methionine metabolism by MAT2A in hepatocellular carcinoma"**
*Authors: Chen L. et al.*
摘要：通过免疫组化(使用MAT2A特异性抗体)发现肝癌组织中MAT2A表达显著升高，其水平与患者预后负相关，并参与调控肿瘤细胞的甲硫氨酸代谢重编程。
3. **"Structural insights into MAT2A function through antibody-based inhibition studies"**
*Authors: Rodriguez R. et al.*
摘要：开发了高特异性MAT2A单克隆抗体，通过X射线晶体学解析抗体-抗原结合表位，揭示了MAT2A催化结构域的关键功能区域，为靶向药物设计提供依据。
注：以上内容为领域知识模拟，具体文献需通过PubMed/Google Scholar检索关键词"MAT2A antibody"+"cancer/metabolism/inhibitor"获取。真实研究多集中于MAT2A在癌症代谢、表观遗传调控及小分子抑制剂开发领域。
The methionine adenosyltransferase 2 alpha (MAT2A) antibody is a research tool designed to detect and study the MAT2A enzyme, a critical player in methionine metabolism. MAT2A catalyzes the synthesis of S-adenosylmethionine (SAMe), the primary methyl donor for methylation reactions essential for DNA/RNA modification, protein regulation, and neurotransmitter synthesis. Unlike its isoform MAT1A (liver-specific), MAT2A is widely expressed in extrahepatic tissues, including the brain, kidneys, and proliferating cells, making it vital during development and cellular growth. Dysregulation of MAT2A is linked to pathologies such as cancer, neurodegenerative disorders, and liver diseases, where altered SAMe levels disrupt epigenetic and metabolic homeostasis.
MAT2A antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and abundance in disease models or drug-response studies. They aid in exploring MAT2A's role in cancer progression, particularly in tumors reliant on methionine cycle activity, and its potential as a therapeutic target. Recent interest has surged due to MAT2A inhibitors being investigated for cancers with methylthioadenosine phosphorylase (MTAP) deletions. These antibodies are typically validated for specificity across species (human, mouse, rat) and sample types (cell lysates, tissues), ensuring reliability in both basic and translational research. Their application advances understanding of cellular metabolism and supports drug discovery efforts targeting SAMe-dependent pathways.
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