| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DBA; DBA1; Ribosomal protein S19; rps19; S19;;RPS19 |
| WB Predicted band size | 16 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human RPS19 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于RPS19抗体的3篇代表性文献的简要总结(文献信息为示例性概括，具体内容需根据实际文献调整)：
1. **文献名称**：*RPS19 mutations impair ribosome assembly and cause Diamond-Blackfan anemia through altered antibody reactivity*
**作者**：Gazda HT, et al.
**摘要**：研究通过RPS19抗体检测发现，Diamond-Blackfan贫血(DBA)患者的RPS19蛋白表达异常，揭示了RPS19突变导致核糖体组装缺陷的分子机制。
2. **文献名称**：*Development of a monoclonal antibody specific for human RPS19 and its application in cancer diagnostics*
**作者**：Chen J, et al.
**摘要**：报道一种新型RPS19单克隆抗体的开发，并验证其在乳腺癌和白血病组织中的高特异性，提示RPS19可能作为肿瘤生物标志物的潜力。
3. **文献名称**：*RPS19 antibody reveals cytoplasmic mislocalization in Diamond-Blackfan anemia patient cells*
**作者**：Flygare J, et al.
**摘要**：利用免疫荧光技术结合RPS19抗体，发现DBA患者细胞中RPS19蛋白的胞质定位异常，为疾病病理机制提供了亚细胞水平证据。
(注：以上文献信息为基于领域知识的示例性描述，实际引用需以真实文献为准。)
**Background of RPS19 Antibody**
The RPS19 antibody targets ribosomal protein S19 (RPS19), a component of the 40S subunit of eukaryotic ribosomes. RPS19 plays a critical role in ribosome biogenesis, facilitating rRNA processing and ribosome assembly. Dysregulation of RPS19 is linked to Diamond-Blackfan anemia (DBA), a rare inherited bone marrow failure syndrome characterized by defective erythropoiesis. Approximately 25% of DBA cases are attributed to heterozygous mutations in the *RPS19* gene, leading to impaired ribosome function and p53-mediated cellular stress responses.
RPS19 antibodies are essential tools for studying ribosomopathies and related molecular mechanisms. They enable the detection and localization of RPS19 in cellular and tissue samples, aiding research into its expression patterns, interactions, and role in hematopoiesis. These antibodies are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate how RPS19 dysfunction contributes to pathological conditions.
Additionally, RPS19 antibodies have diagnostic potential, helping identify DBA patients with *RPS19* mutations and guiding therapeutic strategies. Their application extends to exploring broader roles of ribosomal proteins in cancer, aging, and metabolic disorders. By elucidating RPS19's molecular pathways, these antibodies support the development of targeted therapies for ribosome-related diseases. Overall, RPS19 antibodies are pivotal in bridging basic ribosome biology with clinical insights into human diseases.
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