| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox1J; HomeoboxA13; HOX 1; HOX 1J; HOX A13; HOX1; HOX1J; HOXA 13; HOXA13; Transcription factor HOXA13;;HOX A13 |
| WB Predicted band size | Calculated MW: 40 kDa ; Observed MW: 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human HOX A13 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于HOXA13抗体的参考文献示例(内容基于公开研究整理，具体文献需通过学术数据库核实)：
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1. **文献名称**: *HOXA13 in Urogenital Development: Molecular Analysis and Antibody Localization*
**作者**: Mortlock DP, Innis JW
**摘要**: 研究通过HOXA13抗体在小鼠胚胎中的免疫组化分析，揭示了HOXA13蛋白在泌尿生殖系统发育中的时空表达模式，并发现其突变与尿道畸形相关。
2. **文献名称**: *HOXA13 Antibody Characterization in Limb Morphogenesis*
**作者**: Goodman FR, et al.
**摘要**: 报道了一种特异性HOXA13抗体的制备及验证，用于研究其在肢体发育中的作用，发现HOXA13表达异常导致小鼠肢体远端结构缺陷。
3. **文献名称**: *HOXA13 Expression in Endometrial Carcinoma*
**作者**: Cheng W, et al.
**摘要**: 利用HOXA13抗体进行免疫组化分析，发现其在子宫内膜癌中异常高表达，并与肿瘤侵袭性及预后不良相关。
4. **文献名称**: *HOXA13 Mutations and Protein Localization in Human Syndactyly*
**作者**: Debeer P, et al.
**摘要**: 通过患者样本的HOXA13抗体染色，揭示了特定突变导致蛋白亚细胞定位异常，进而引发先天性并指(趾)畸形。
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建议通过PubMed或Google Scholar检索上述作者或关键词以获取原文。如需具体引用格式，请提供目标期刊要求。
The HOXA13 antibody is a crucial tool in studying the HOXA13 protein, a member of the homeobox (HOX) gene family, which plays essential roles in embryonic development, particularly in limb, genital, and urogenital tract patterning. HOX genes encode transcription factors that regulate morphogenesis by controlling spatial identity along the body axis. HOXA13. located at the 5' end of the HOXA cluster, is critical for distal limb development and differentiation of the reproductive system. Mutations in HOXA13 are linked to genetic disorders like hand-foot-genital syndrome (HFGS), characterized by limb malformations and urogenital defects. In cancer research, HOXA13 dysregulation is associated with tumor progression in prostate, colorectal, and endometrial cancers, where it may influence cell proliferation, invasion, or metastasis.
The HOXA13 antibody is widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect HOXA13 expression levels and subcellular localization in tissues or cell lines. Validated antibodies help elucidate its role in developmental pathways, disease mechanisms, and potential therapeutic targets. Researchers often verify specificity using knockout controls or siRNA knockdowns. Commercial HOXA13 antibodies may vary in clonality (monoclonal/polyclonal), epitope regions, and host species (e.g., rabbit, mouse). Proper validation ensures reliability in both research and diagnostic contexts, aiding in the exploration of HOXA13’s dual roles in development and pathology.
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