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Rabbit Monoclonal DopamineReceptorD3 Antibody

  • 中文名： DopamineReceptorD3抗体
  • 别    名： D(3) dopamine receptor; Dopamine D3 receptor; DRD3; ETM1; FET1;;DRD3
货号: IPDX18008
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesD(3) dopamine receptor; Dopamine D3 receptor; DRD3; ETM1; FET1;;DRD3
WB Predicted band size44 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human DRD3
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇与多巴胺受体D3(DRD3)抗体相关的文献摘要示例：

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1. **"Characterization of a novel dopamine D3 receptor antibody for immunoblotting and immunohistochemistry"**

- **作者**: Smith A, et al.

- **摘要**: 本研究开发并验证了一种高特异性的人和小鼠DRD3抗体，通过Western blot和免疫组化证实其与DRD3的结合能力，且与其他多巴胺受体(如D2)无交叉反应，适用于神经组织中的定位研究。

2. **"Dopamine D3 receptor expression in schizophrenia: Insights from post-mortem brain analysis"**

- **作者**: Lee B, et al.

- **摘要**: 使用DRD3特异性抗体对精神分裂症患者脑组织进行检测，发现前额叶皮层中DRD3蛋白水平显著升高，提示其可能在疾病病理中通过突触可塑性失调发挥作用。

3. **"Selective targeting of dopamine D3 receptors in addiction models: Antibody-based modulation studies"**

- **作者**: Johnson C, et al.

- **摘要**: 通过DRD3抗体阻断实验，证明抑制DRD3活性可减少可卡因成瘾模型中的药物寻求行为，支持DRD3作为治疗成瘾的潜在靶点。

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注：以上文献名为模拟示例，实际文献需通过数据库(如PubMed、Google Scholar)检索关键词“Dopamine Receptor D3 antibody”或“DRD3 antibody”获取。建议优先选择近年发表(如近5年)且经过同行评审的研究。

背景信息

The dopamine receptor D3 (DRD3) is a G protein-coupled receptor predominantly expressed in limbic regions of the brain, such as the nucleus accumbens, striatum, and globus pallidus. It plays a key role in regulating emotional, cognitive, and reward-related behaviors, with implications in neuropsychiatric disorders like addiction, schizophrenia, and Parkinson’s disease. DRD3 antibodies are essential tools for detecting and quantifying this receptor in research. They enable the study of DRD3 expression patterns, localization, and alterations under pathological or pharmacological conditions using techniques like Western blotting, immunohistochemistry, or immunofluorescence. A major challenge in developing DRD3 antibodies lies in ensuring specificity, as DRD3 shares high sequence homology (particularly in transmembrane domains) with the closely related DRD2 receptor. To address this, antibodies are often designed against unique epitopes in the N-terminal extracellular domain or third intracellular loop. These antibodies have advanced studies exploring DRD3's role in modulating dopamine signaling pathways, synaptic plasticity, and behavioral responses. Additionally, they support drug development efforts targeting DRD3 for treating substance use disorders or movement disorders. Recent research also utilizes DRD3 antibodies to investigate receptor dimerization, trafficking, and interactions with ligands or antipsychotic drugs, providing insights into therapeutic mechanisms and disease biomarkers.

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