| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GAB B R2; GABA-BR2; GABABR2; GABB R2; Gabbr2; Gb2; GPR51; GPRC 3B; HG20; R2 SUBUNIT;;GABA B receptor 2 |
| WB Predicted band size | 106 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human GABA B receptor 2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于GABAB受体2(GABABR2)抗体的3篇代表性文献的简要信息：
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1. **文献名称**：*Cloning and characterization of a novel GABAB receptor subunit, GABABR2*
**作者**：Kaupmann, K. et al.
**摘要**：该研究首次克隆并鉴定了GABABR2亚基，开发了特异性抗体用于检测其在脑组织中的表达分布，证实GABABR1与GABABR2需共表达才能形成功能性受体。
2. **文献名称**：*Role of heteromer formation in GABAB receptor function*
**作者**：Jones, K.A. et al.
**摘要**：通过抗GABABR2的抗体进行免疫共沉淀实验，证明GABABR1和R2在神经元中形成异源二聚体，并揭示了R2亚基在受体膜运输及信号转导中的关键作用。
3. **文献名称**：*GABAB receptor antibodies in neurological disorders: functional characterization*
**作者**：Doly, S. et al.
**摘要**：利用GABABR2特异性抗体研究其在癫痫和疼痛模型中的作用，发现抗体阻断R2可抑制受体下游信号通路，为相关疾病治疗提供分子机制依据。
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**备注**：以上文献为示例性概括，实际引用时建议通过PubMed或Google Scholar以“GABAB receptor 2 antibody”“GABABR2 function”等关键词检索最新研究，并核对具体实验背景。
The GABAB receptor is a metabotropic GABA receptor that mediates slow inhibitory signaling in the central nervous system. It functions as a heterodimer composed of GABAB1 and GABAB2 subunits. The GABAB2 subunit plays a critical role in trafficking the receptor to the cell surface and facilitating G-protein coupling for downstream signaling. Antibodies targeting GABAB receptor 2 (GABABR2) are essential tools for studying the expression, localization, and functional roles of this receptor in neurological processes.
These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect GABABR2 in tissues or cultured cells. They help researchers investigate receptor distribution in brain regions involved in synaptic plasticity, neurotransmitter release modulation, and conditions like epilepsy, anxiety, and chronic pain. Specificity validation (e.g., knockout controls) is crucial, as cross-reactivity with related proteins may occur.
Studies using GABABR2 antibodies have advanced understanding of its interactions with ligands, regulatory proteins, and therapeutic targets. Dysregulation of GABAB receptors is linked to neurological and psychiatric disorders, making these antibodies valuable for both basic research and drug development. Commercial variants are typically raised in rabbits or mice, with reactivity confirmed across human, mouse, and rat samples.
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