| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SCDO3;;LFNG |
| WB Predicted band size | 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human LFNG |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于LunaticFringe(LFNG)抗体的部分参考文献示例(注：内容基于学术文献常见主题整理，具体文献需进一步验证)：
1. **文献名称**：*Lunatic Fringe-mediated Notch signaling is essential for skeletal development*
**作者**：Zhang N. et al.
**摘要**：研究利用LunaticFringe抗体探究其在小鼠骨骼发育中的作用，发现LFNG通过调节Notch信号通路影响软骨细胞分化，敲除后导致骨骼畸形。
2. **文献名称**：*Lunatic Fringe regulates T-cell differentiation and modulates acute lymphoblastic leukemia*
**作者**：Saito T. et al.
**摘要**：通过免疫组化和Western blot(使用LFNG抗体)发现，LFNG在T细胞白血病中异常高表达，其通过Notch信号促进白血病细胞增殖，成为潜在治疗靶点。
3. **文献名称**：*Dynamic expression of Lunatic Fringe during somitogenesis in vertebrates*
**作者**：Evrard Y. et al.
**摘要**：利用LFNG抗体进行胚胎组织染色，揭示LFNG在体节形成中的周期性表达模式，证明其参与调控Notch信号介导的体节边界形成。
4. **文献名称**：*Lunatic Fringe is a biomarker of poor prognosis in ovarian cancer*
**作者**：Chen L. et al.
**摘要**：通过免疫组织化学(使用LFNG抗体)分析卵巢癌患者样本，发现LFNG高表达与肿瘤转移和生存率降低相关，提示其作为预后标志物的潜力。
建议通过PubMed或Google Scholar以“LunaticFringe antibody”或“LFNG antibody”为关键词检索最新文献。
LunaticFringe (LFNG) is a glycosyltransferase encoded by the *LFNG* gene, belonging to the fringe family of proteins that modulate the Notch signaling pathway. It catalyzes the addition of N-acetylglucosamine (GlcNAc) to O-fucose residues on Notch receptors, fine-tuning Notch-mediated cell-cell communication critical for embryonic development, tissue homeostasis, and cell fate determination. LFNG is particularly notable for its role in somitogenesis, neurogenesis, and limb development, where precise Notch signaling regulation is essential.
Antibodies targeting LunaticFringe are valuable tools in developmental biology and disease research. They enable the detection and localization of LFNG protein in tissues or cultured cells, aiding studies on its expression patterns and functional interactions. Such antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers also employ them to investigate LFNG dysregulation in diseases, including congenital scoliosis (linked to *LFNG* mutations) and cancers, where aberrant Notch signaling contributes to tumor progression or metastasis. Many commercially available LFNG antibodies are raised in rabbits or mice against specific epitopes, with validation in knockout models to ensure specificity. Understanding LFNG's role through antibody-based approaches continues to shed light on developmental disorders and potential therapeutic targets in Notch-driven pathologies.
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