| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CDHF1; DG2/DG3; DSC1;;Desmocollin 1 |
| WB Predicted band size | 100 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Desmocollin 1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Desmocollin1(DSC1)抗体的3篇示例文献(仅供参考，实际文献需通过学术数据库检索确认)：
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1. **文献名称**：*Autoantibodies against desmocollin-1 in pemphigus vulgaris*
**作者**：Müller R, et al.
**摘要**：该研究报道了寻常型天疱疮患者体内存在针对Desmocollin1的自身抗体，并揭示了这些抗体通过破坏桥粒结构导致表皮细胞间黏附丧失的机制。
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2. **文献名称**：*Characterization of a monoclonal antibody specific for desmocollin 1: Differential expression in normal human tissues and tumors*
**作者**：Kurzen H, et al.
**摘要**：研究开发了一种特异性识别Desmocollin1的单克隆抗体，并验证其在正常组织和肿瘤中的差异性表达，提示DSC1可能在癌症发展中起调控作用。
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3. **文献名称**：*Desmocollin 1 is critical for epidermal barrier function by regulating tight junction integrity*
**作者**：Chen J, et al.
**摘要**：利用DSC1抗体进行功能研究，发现Desmocollin1通过调控紧密连接蛋白表达维持表皮屏障功能，为皮肤炎症性疾病提供了新的治疗靶点。
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**建议**：以上为示例文献，实际引用时可通过PubMed或Web of Science检索关键词(如"Desmocollin1 antibody" "DSC1 autoantibody")，筛选近年高被引或权威期刊研究。
Desmocollin1 (Dsc1) is a member of the desmocollin family of calcium-dependent transmembrane glycoproteins, which are essential components of desmosomes—intercellular junctions critical for maintaining tissue integrity in epithelial and other tissues. As a key adhesion molecule, Dsc1 plays a vital role in cell-cell adhesion by mediating homophilic and heterophilic interactions with other desmosomal cadherins, such as desmogleins. Structurally, it consists of an extracellular domain responsible for calcium-dependent binding, a transmembrane region, and a cytoplasmic tail that interacts with intracellular plaque proteins like plakoglobin and desmoplakin to anchor intermediate filaments to the plasma membrane.
Dsc1 is predominantly expressed in stratified epithelia, including the skin, where it contributes to epidermal barrier function and cellular differentiation. Antibodies targeting Dsc1 have become valuable tools in research and diagnostics. In autoimmune blistering disorders like pemphigus vulgaris or subcorneal pustular dermatosis, anti-Dsc1 autoantibodies can disrupt desmosomal adhesion, leading to acantholysis and tissue fragility. Additionally, Dsc1 antibodies are used experimentally to study desmosome assembly, epithelial morphogenesis, and wound healing. Recent studies also explore its role in cancer, as altered Dsc1 expression correlates with tumor progression and metastasis in certain carcinomas. The development of monoclonal and polyclonal Dsc1 antibodies continues to advance understanding of desmosome biology and disease mechanisms.
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