| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HSPC150; PIG50; Ube2t;;UBE2T |
| WB Predicted band size | 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human UBE2T |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于HSPC150抗体的3篇示例文献(内容为模拟，实际引用请核实)：
1. **文献名称**：*HSPC150 regulates hepatocellular carcinoma progression via Wnt/β-catenin signaling*
**作者**：Zhang Y, et al.
**摘要**：研究通过HSPC150抗体检测其在肝癌组织中的高表达，揭示其通过激活Wnt通路促进肿瘤侵袭的机制。
2. **文献名称**：*UBE2Q1 (HSPC150) promotes tumor angiogenesis through VEGF stabilization in colorectal cancer*
**作者**：Lee S, et al.
**摘要**：利用HSPC150抗体进行免疫组化分析，发现其通过泛素化修饰稳定VEGF蛋白，驱动结直肠癌血管生成。
3. **文献名称**：*HSPC150 knockdown inhibits cell cycle progression via p53-dependent pathway*
**作者**：Chen X, et al.
**摘要**：通过抗体Western blot验证HSPC150在细胞周期中的调控作用，其缺失导致p53激活和G1期阻滞。
4. **文献名称**：*HSPC150 interacts with α-synuclein in Parkinson's disease models*
**作者**：Wang H, et al.
**摘要**：采用HSPC150抗体共免疫沉淀技术，发现其与α-突触核蛋白相互作用，可能参与帕金森病的蛋白聚集过程。
(注：以上为假设性文献，实际研究需查阅PubMed等数据库获取准确信息。)
**Background of HSPC150 Antibody**
The HSPC150 antibody targets the Hematopoietic Stem/Progenitor Cell 150 (HSPC150) protein, also known as UBE2Q1. a member of the ubiquitin-conjugating enzyme (E2) family. This protein is implicated in the ubiquitin-proteasome system, which regulates protein degradation, cell cycle progression, and apoptosis. HSPC150 was initially identified in hematopoietic stem/progenitor cells but is expressed in various tissues, suggesting broader biological roles.
Structurally, HSPC150 contains a conserved ubiquitin-conjugating (UBC) domain at its N-terminus, critical for its enzymatic activity. Studies highlight its involvement in cancer biology, with upregulated expression observed in malignancies like breast cancer, colorectal cancer, and glioblastoma, correlating with tumor progression and therapeutic resistance.
HSPC150 antibodies are essential tools for detecting the protein’s expression and localization via techniques such as Western blotting, immunohistochemistry (IHC), and flow cytometry. Research using these antibodies has helped elucidate HSPC150’s interaction with E3 ubiquitin ligases and substrates, shedding light on its regulatory mechanisms in cellular processes.
Despite its known associations, HSPC150’s precise physiological and pathological functions remain under investigation. Ongoing studies aim to clarify its role in stem cell maintenance, oncogenesis, and as a potential biomarker or therapeutic target. The HSPC150 antibody thus serves as a critical reagent in both basic research and translational oncology.
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