| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cellular retinoic acid binding protein 2; Cellular retinoic acid binding protein II ; Crabp2; CRABPII; RBP6;;CRABP2 |
| WB Predicted band size | Calculated MW: 16 kDa ; Observed MW: 14 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human CRABP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
+ +
以下是3篇涉及CRABP2抗体的研究文献摘要简述：
1. **文献名称**：CRABP2 as a Biomarker in Cutaneous Squamous Cell Carcinoma
**作者**：Smith J, et al.
**摘要**：该研究通过免疫组化(使用CRABP2特异性抗体)发现，CRABP2在皮肤鳞状细胞癌中高表达，且与肿瘤侵袭性相关，提示其可作为预后标志物。
2. **文献名称**：Retinoic Acid Signaling and CRABP2 in Breast Cancer Progression
**作者**：Lee S, Kim D.
**摘要**：利用Western blot和免疫荧光(CRABP2抗体)，证明CRABP2通过调控视黄酸信号通路促进乳腺癌细胞迁移，其表达水平与患者生存率负相关。
3. **文献名称**：CRABP2 Expression in Neuronal Differentiation
**作者**：Chen L, et al.
**摘要**：研究采用CRABP2抗体进行流式细胞术分析，发现CRABP2在神经元分化早期显著上调，表明其在神经干细胞定向分化中起关键作用。
4. **文献名称**：CRABP2 as a Target in Pancreatic Cancer Therapy
**作者**：Wang Y, et al.
**摘要**：通过CRABP2抗体染色和基因沉默实验，证实抑制CRABP2可增强胰腺癌细胞对化疗药物的敏感性，为联合治疗提供新靶点。
注：以上文献信息为示例性质，实际引用需核实具体来源及细节。
Cellular retinoic acid-binding protein 2 (CRABP2) is a small intracellular lipid-binding protein that facilitates the transport and metabolism of retinoic acid (RA), a derivative of vitamin A critical for cellular differentiation, proliferation, and embryonic development. CRABP2 belongs to the fatty acid-binding protein (FABP) family and shares structural homology with CRABP1. though their functions differ. Unlike CRABP1. which sequesters RA in the cytoplasm, CRABP2 delivers RA to nuclear retinoic acid receptors (RARs), enabling RA-mediated gene regulation. This protein is highly expressed in tissues undergoing rapid differentiation, such as skin, neural crest cells, and certain cancers.
CRABP2 antibodies are immunological tools used to detect and study the expression, localization, and function of CRABP2 in research and diagnostic contexts. These antibodies are crucial for investigating CRABP2's role in cancer progression, as its overexpression is linked to tumor aggressiveness in breast, ovarian, and lung cancers. They are also employed in developmental biology to explore RA signaling pathways. CRABP2 antibodies are typically validated for applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), with species reactivity spanning humans, mice, and rats. Commercial CRABP2 antibodies are often raised in rabbits or mice, targeting specific epitopes to ensure specificity. Their utility extends to studying therapeutic responses, as CRABP2 modulates the efficacy of retinoid-based treatments in dermatological and oncological contexts.
×
