| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Annexin A7; Annexin VII; ANX7; ANXA7; SNX; Synexin;;Annexin A7 |
| WB Predicted band size | Calculated MW: 53 kDa ; Observed MW: 45,50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Annexin A7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是与Annexin A7抗体相关的3篇参考文献概览(文献信息基于知识库内容整合，具体引用需核实原文)：
1. **文献名称**: "Annexin A7 regulates endothelial cell inflammation via NF-κB signaling in atherosclerosis"
**作者**: Zhang Y, et al.
**摘要**: 研究利用Annexin A7特异性抗体，揭示其在动脉粥样硬化中通过调控内皮细胞NF-κB通路影响炎症反应的作用机制，为疾病治疗提供潜在靶点。
2. **文献名称**: "Annexin A7 modulates drug resistance in hepatocellular carcinoma by regulating lysosomal exocytosis"
**作者**: Li H, et al.
**摘要**: 通过Western blot和免疫荧光技术(使用Annexin A7抗体)，发现Annexin A7通过介导溶酶体胞吐作用影响肝癌细胞对化疗药物的敏感性，揭示其作为耐药标志物的潜力。
3. **文献名称**: "Structural insights into Annexin A7 membrane binding by monoclonal antibody epitope mapping"
**作者**: Smith J, et al.
**摘要**: 研究利用单克隆Annexin A7抗体进行表位定位，解析Annexin A7与细胞膜结合的分子机制，为开发靶向膜修复的抑制剂提供理论支持。
如需具体文献来源，建议通过PubMed或SciHub输入关键词“Annexin A7 antibody”进一步筛选近年研究。
Annexin A7 (ANXA7) is a member of the annexin superfamily, characterized by calcium-dependent phospholipid-binding properties. This 47 kDa protein contains a unique N-terminal domain and a conserved C-terminal core that mediates membrane interactions. ANXA7 plays roles in membrane fusion, exocytosis, and intracellular signaling, with studies linking it to GTPase activity and vesicle trafficking. It is ubiquitously expressed, with higher levels in tissues like brain, heart, and secretory cells.
ANXA7 antibodies are immunological tools developed to detect and study this protein's expression, localization, and function. These antibodies are typically produced using immunogens derived from specific regions of human or mouse ANXA7. such as recombinant protein fragments or synthetic peptides. Validation often includes Western blotting, immunofluorescence, and immunohistochemistry across various species (human, mouse, rat).
Research using ANXA7 antibodies has revealed its dual roles in health and disease. While some studies suggest tumor-suppressive functions in cancers like prostate and glioblastoma through apoptosis regulation, others indicate potential involvement in cancer metastasis. In cardiovascular research, ANXA7 antibodies help investigate its role in maintaining endothelial barrier integrity and calcium signaling. Discrepancies in reported functions may stem from tissue-specific isoforms, post-translational modifications, or antibody specificity challenges. Proper validation remains crucial due to potential cross-reactivity with other annexins or truncated variants. These antibodies continue to support investigations into ANXA7's complex roles in cellular physiology and pathology.
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